| Participants list |
Industries
Abbott Bioresearch Center, USA
Abbott Laboratories, USA
ActivX Biosciences, USA
ADV Bioscience LLC, USA
AstraZeneca, UK
Biogen Idec, Inc., USA
BioPerspectives, USA
Boehringer Ingelheim Pharma GmbH, Germany
Boryung Pharmaceutical Company, Korea
Bruker daltonik GmbH, Germany
Cangen Biotechnologies, USA
Cellzome AG, USA
Centocor R&D Inc., USA
CSIRO Molecular & Health Technologies, Australia
DSM Biologics Company BV, The Netherlands
Eprogen, Inc., USA
Eureka Therapeutics Inc., USA
F. Hoffmann-La Roche, Switzerland
Fluorotronics, Inc., USA
FOGALE Nanotech, France
GE Global Research Center, USA
Genetix, UK.
GenScript Corporation, USA
Genzyme, Switzerland
Hoffmann-LaRoche Inc., USA
HTL Biosolutions Inc., USA.
JENEIL BioProducts GmbH, Germany
Kyorin Pharmaceutical Co., LTD., USA
Lectus Therapeutics Ltd, UK
Life Technologies, USA
Medarex Inc., USA
Medicinal Chemistry, UCB, UK
MedImmune LLC, USA
Merck & Co., Inc., USA
Millipore Corporation, USA
Nerviano Medical Sciences, Italy
NeuroDrug Consulting, USA
Novartis, China
Novozymes A/S, Denmark
PamGene BV, The Netherlands
Pfizer Global Research and Development, USA
Pharmadiscover Inc., China
Prolexys Pharmaceuticals, USA
Rainbow Bioscience, LLC, USA
Sanofi Pasteur, France
Seattle Genetics, USA
Sigma-Aldrich Biotechnology, USA
Sundia MediTech Company, Ltd., China
SuppreMol GmbH, Germany
Trellis Bioscience, USA
Vitae Pharmaceuticals Inc., USA
Vybion,Inc., USA
Wyeth Research, USA
Academia
Advanced Science Institute, Japan
Agricultural Research Council( CRA ), Italy
AIIMS, India
AIST Tokyo Waterfront, Japan
Biotechnology Research Institute, Canada
Boston University School of Medicine, USA
Brussels Center for Redox Biology, Belgium
Butler University, USA
Cardiff University, UK
Case Western Reserve University School of Medicine, USA
Cell Surface Signalling Laboratory, UK
Centinela Freeman Memorial Hospital, USA
Central Division of Analytical Chemistry, Germany
Chemistry RAMS, Russia
Children's Hospital of Orange County, USA
Clinical Proteomics Center, Taiwan
Consortium for Genomic Technologies, Italy
Cornell University, USA
Craig Venter Institute, USA
Dalhousie University, Canada
Department of Chemistry, University of Ioannina, Greece
Eindhoven University of Technology, The Netherlands
Erasmus Medical Center, Netherlands
ETH Zurich, Switzerland
Federal University of Rio de Janeiro, Brazil
Florida State University, USA
Fox Chase Cancer Center, USA
Fred Hutchinson Cancer Research Center, USA
Georgia Institute of Technology, USA
Goethe University, Germany
Hannam University, Korea
Harvard University, USA
HELIOS Klinikum Berlin-Buch and Experimental and Clinical Research Center, Germany
Hiroshima University, Japan
Hungarian Academy of Sciences, Hungary
Ibaraki University, Japan
Idaho State University, USA
Indiana University, USA
Institut de Pharmacologie Moléculaire et Cellulaire, France
Institut Pasteur de Lille, France
Institute for Biology and Chemistry of Proteins, France
Institute of Mechanics Bulgarian Academy of Sciences, Bulgaria
Institute of Microbial Technology, India
Institute of Molecular Biology and Biological Physics, USA
Iwate medical University, Japan
Jamia Millia Islamia(Central University), India
Johns Hopkins Hospital, USA
Johns Hopkins University School of Medicine, USA
Joseph Fourrier University, France
Karolinska University Hospital, Sweden
Katholieke Universiteit, Belgium
King Saud University, Kingdom of Saudi Arabia
Kyoto University, Japan
Kyungpook National University, Korea
Liver Research Center & Department of Hepato-Gastroenterology, Taiwan
London Research Institute, UK
M. D. Anderson Cancer Center, USA
Masaryk University, Czech Republic
Max-Planck Institute of Molecular Physiology, Germany
McGill University, Canada
McMaster University, Canada
Middle East Technical University, Turkey
Midwestern University, USA
MIT, USA
Moffitt Cancer Center & Research Institute, USA
Monash University, Australia
Mount Sinai School of Medicine, USA
Nara Institute of Science and Technology, Japan
Nara Women's University, Japan
National Institutes of Health, USA
National University of Singapore, Singapore
Newcastle University, UK
Northwest A & F University, China
Osaka University, Japan
oungnam University, Korea
Padmashree Dr. D.Y. Patil University, India
Princeton University, USA
Proteomics International, Australia
PSG College of Pharmacy, India
Rensselaer Polyechnic Institute, USA
Rice University, USA
Second Affiliated Hospital of Soochow University, China
Sejong University, Korea
Seoul National University, Korea
St. Jude Children's Research Hospital, USA
Stanford University, USA
State University of New York, USA
Stony Brook University, USA
Stowers Institute for Medical Research, USA
The Chinese University of Hong Kong, China
The Hebrew University of Jerusalem, Israel
The Italian Institute of Technology, Italy
The Ohio State University, USA
The University of Adelaide, Australia
The University of Iowa, USA
The University of Kansas, USA
The University of Melbourne, Australia
The University of North Carolina at Chapel Hill, USA
The University of Tokyo, Japan
The University of Texas M.D. Anderson Cancer Center, USA
Tohoku University, Japan
United States Department of Agriculture, USA
Universidad Nacional Autnoma de Mxico, Mexico City
Universita degli studi di pavia, Italy
Université de Montréal, Canada
Universite de Sherbrooke, Canada
Université Paris, France
Université Rennes, France
University College London, UK
University Graz, Austria
University in Innsbruck, Austria
University of Bristol, UK
University of California, USA
University of Chicago, USA
University of Chicago, USA
University of Cincinnati, USA
University of Erlangen-Nuremberg, Germany
University of Florida College of Medicine, USA
University of Haifa, Israel
University of Heidelberg, Germany
University of Hong Kong, China
University of Illinois, USA
University of Ioannina, Greece
University of Leeds, UK
University of Leeds, UK
University of Liverpool Cancer Research Centre, UK
University of Malaya centre for Proteomics research, Malaysia
University of Medical Sciences, Iran
University of Melbourne, Australia
University of Michigan, USA
University of Minnesota, USA
University of Mississippi Medical Center, USA
University of Miyazaki, Japan
University of Montreal, Canada
University of Munich, Germany
University of North Carolina at Chapel Hill, USA
University of North Carolina, USA
University of Oslo, Norway
University of Otago, Christchurch Cardioendocrine Research Group, New Zealand
University of Oulu, Finland
University of Oulu, Finland
University of Pennsylvania, USA
University of Pittsburgh Drug Discovery Institute, USA
University of Pittsburgh School of Medicine, USA
University of Pittsburgh, USA
University of Portsmouth, UK
University of Rochester School of Medicine and Dentistry, USA
University of Science and Technology of Lille, France
University of South Australia, Australia
University of Stuttgart, Germany
University of Tartu, Estonia
University of Texas Medical Branch, USA
University of Texas, USA
University of Tokyo, Japan
University of Toronto, Canada
University of Virginia, USA
University of Washington, USA
University of Waterloo, Canada
University of Western Ontario, Canada
University of Western Sydney, Australia
University of Zagreb, Croatia
University of Zürich, Switzerland
University of California, USA
University of Houston, USA
University of Illinois College of Medicine, USA
University of Massachusetts Medical School, USA
University of Pittsburgh School of Medicine, USA
Uppsala University, Sweden
Vanderbilt University Medical Center, USA
Vanderbilt University, USA
Walter and Eliza Hall Institute of Medical Research, Australia
Weill Medical College of Cornell University, USA
Yale University School of Medicine, USA
Yale University, USA
Yokohama National University, Japan
Yonsei University, Korea
Youngnam University, Korea
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| Scientific Program |
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BIT Life Sciences' 3 rd Annual PepCon-2010
Theme: After a Solution for the Machines of Life
Time: March 21-23, 2010 Venue: Beijing International Convention Center, Beijing, China |
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Scientific Program |
Experts from both academia and industries are invited to present contemporary information from current research through commercial implementation of new technologies. Time allotted for oral presentations will be 25 to 40 minutes. English is the conference language. You can submit your abstracts by: Abstract Submission |
Time |
Activities |
March 21, 2010
08:00-11:50 |
Opening Ceremony
Moderator
Dr. Jianguo Yang, Principal Scientist and Group Leader, Genzyme, USA |
08:00-08:30 |
Group Photo |
09:00-09:05 |
Chair' s Opening Remark |
09:05-09:35 |
Executives of GO and NGO of Protein Science Organizations
Governmental Regulatory Officers
Leading Scientists
Industrial Leaders in Therapeutic Protein Development |
| Keynote Forum |
09:40-10:05 |
Title: Advances in Proteomic Profiling of Cancers: Alternative Splice Variants as a New Class of Biomarker Candidate
Dr. Gilbert Omenn, Professor, University of Michigan, Leader of Human Plasma Proteome Project (HPPP), USA |
10:05-10:30 |
Title: Structurally Disordered Proteins: Roles in Development
Dr. A. Keith Dunker, T-K Li Professor of Medical Research, Indiana University, Founder/Father of The Protein Trinity, USA |
10:30-10:55 |
Title: The Unfolded Protein Response: Cellular Response That Maintains the Homeostasis of the Endoplasmic Reticulum
Dr. Kazutoshi Mori, Professor, Department of Biophysics, Graduate School of Science, Kyoto University, Japan |
10:55-11:20 |
Title: Molecular Machines Mediating Translocation of Proteins across and into the Membranes of Mitochondria
Dr. Walter Neupert, Chairman of the EMBO Council, Professor , University of Munich, Germany |
11:20-11:45 |
Sponsor Speech
Ms. Catherine TARRADE, New Products Marketing Coordinator, Abcam plc, UK |
|
March 21, 2010
12:00-13:00 |
Luncheon |
March 21, 2010
18:00-20:00 |
Welcome Banquet |
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Symposium 1: Basic Protein Science
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Session 1-1: Advances of Protein Molecular Biology and Cell Biology
Time: March 21, 2010 13:30- 17:30 |
Session Chair |
Dr. Todd R. Graham, Director of Graduate Studies, Department of Biological Sciences, Vanderbilt University, USA |
Co-Chair |
Dr. Walter Neupert, Chairman of the EMBO Council, Professor, University of Munich, Germany |
13:30-13:55 |
Title: Light-activated DNA Binding in a Designed Allosteric Protein
Dr. Tobin Roy Sosnick, Director, Institute for Biophysical Dynamics, Department of Biochemistry & Molecular Biology, University of Chicago, USA |
13:55-14:20 |
Title: Tail-anchored Membrane Protein Biogenesis
Dr. Robert Keenan, Assistant Professor, Dept. of Biochemistry & Molecular Biology, University of Chicago, USA |
14:20-14:45 |
Title: Phospholipid Flippases and Their Influence on Membrane Biogenesis and Vesicular Transport
Dr. Todd R. Graham, Director of Graduate Studies, Department of Biological Sciences, Vanderbilt University, USA |
14:45-15:10 |
Title: Spatial and Temporal Organization of the E. coli PTS Proteins
Dr. Orna Amster-Choder, Professor, Department of Molecular Biology, The Hebrew University Medical School, Israel |
15:10-15:30 |
Coffee Break |
15:30-15:55 |
Title: Uncovering the Molecular Mechanism of High Affinity Interaction between V-ATPase and Small GTPases
Dr. Vladimir Marshansky, Assistant Professor of Medicine, Department of Medicine, Harvard Medical School, USA |
15:55-16:20 |
Title: Functional Analysis of Lysosomal Peptide Transporters in C. elegans
Dr. Takahiro Tanji , Assistant Professor, Department of Immunobiology , School of Pharmacy, Iwate medical University, Japan |
16:20-17:30 |
Panel Discussion |
|
Session 1-2: Protein Folding Dynamics, Stability and Quality Control
Time: March 21, 2010 13:30- 17:30 |
Session Chair |
Dr. Kunihiro Kuwajima, Professor, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Japan |
Co-Chair |
Dr. Thomas Weikl, Group Leader, Department of Theory and Bio-Systems, Max Planck Institute of Colloids and Interfaces, Germany |
13:30-13:55 |
Title: Conformational Changes during Protein Folding and Binding Revealed by Mutational Analysis
Dr. Thomas Weikl, Group Leader, Department of Theory and Bio-Systems, Max Planck Institute of Colloids and Interfaces, Germany |
13:55-14:20 |
Title: FAST Prediction of Protein Thermodynamics
Dr. Donald J. Jacobs, Associate Professor of Physics, University of North Carolina at Charlotte, USA |
14:20-14:45 |
Title: Architectural Role of Idiosyncratic Helix-turn-helix Motif in Methanogenic-type Seryl-tRNA-synthetase
Dr. Ivana Weygand-Durasevic, Professor of Biochemistry, University of Zagreb, Croatia |
14:45-15:10 |
Title: Identification and Stabilization of an Excited State in the Molecular Switch Ras in Order to Modulate Enzyme Activity
Dr. Michael Spoerner, Project Leader, University of Regensburg, Germany |
15:10-15:30 |
Coffee Break |
15:30-15:55 |
Title: Is the Folding Pathway Conserved in Homologous Proteins?
Dr. Kunihiro Kuwajima, Professor, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Japan |
15:55-16:20 |
Title: Stability and Folding of Hyperthermophilic Proteins
Dr. Kazufumi Takano, Associate Professor, Department of Material and Life Science, Osaka University, Japan |
16:20-16:45 |
Title: Single Molecule Study Proves Barrier-Limited Folding Mechanism of PDBA and BBL
Dr. Fang Huang, Professor, Center for Bioengineering and Biotechnology, China University of Petroleum (Huadong), China |
16:45-17:30 |
Panel Discussion |
|
Session 1-3: Protein-Protein Interactions and Protein-Transduction
Time: March 22, 2010 08:30-12:10 |
Session Chair: |
Dr. Mario Rivera, Professor of Chemistry, The University of Kansas, USA |
Co-Chair: |
Dr. Moonsoo Jin, Biomedical Engineering, Cornell University, USA |
08:30-08:55 |
Title: Protein Dynamics and Protein-Protein Interaction Processes at Play in the Traffic of Iron In and Out of the Bacterioferritin Cavity
Dr. Mario Rivera, Professor of Chemistry, The University of Kansas, USA |
08:55-09:20
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Title: Structure-based Design of a D-amino Acid Peptide Inhibitor of Tau Fibrillation
Dr. John Karanicolas, Assistant Professor, University of Kansas, USA |
09:20-09:45 |
Title: In Vivo Detection of Protein-Protein Interactions: Application to the Engineering of Activation-Specific Antagonist against Integrins
Dr. Moonsoo Jin, Biomedical Engineering, Cornell University, USA |
09:45-10:05 |
Coffee Break |
10:05-10:30 |
Title: Evidence for a Protein-Protein Interaction between Human Serum Transferrin and Ceruloplasmin
Dr. Thanh Ha Duong, Laboratoire ITODYS, Université Paris, France |
10:30-10:55 |
Title: Engineered Fluorescent and Bioluminescent Proteins to Visualize Biological Function in Living Cells
Dr. Takeaki Ozawa, Professor of Chemistry, Department of Chemistry, School of Science, The University of Tokyo, Japan |
10:55-11:20 |
Title: Protein Biotinylation: An Example of a Post-translational Modification of Exceptional Specificity
Dr. Steven Polyak, The University of Adelaide, Australia |
11:20-11:45 |
Title: Detections of p53 cDNA and p53 Protein Mutation in Cancer Cell Lysates Using Surface Plasmon Resonance
Dr. Feimeng Zhou, Professor, California State University, USA |
11:45-12:10 |
Panel Discussion |
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Session 1-4: Proteins Interacting with DNA and RNA
Time: March 22, 2010 08:30-12:10 |
Session Chair: |
Dr. Ching-Hwa Kiang, Physics & Astronomy, Rice University, USA |
Co-Chair: |
Dr. Philippe Collas, Professor of Medical Biochemistry, University of Oslo, Norway |
08:30-08:55 |
Keynote Speaker:
Title: Protein and DNA Interactions Studied Using Single-Molecule Manipulation
Dr. Ching-Hwa Kiang, Physics & Astronomy, Rice University, USA |
08:55-09:20
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Title: Coupling of Endonuclease and Translocase Functions in Type I Restriction-Modification Complexes
Dr. Rudiger Ettrich, Associate Professor, Department of Structure and Function of Proteins, Institute of Systems Biology and Ecology, Academy of Sciences of the Czech Republic, Czech Republic |
09:20-09:45 |
Title: Biophysical Studies of mRNA-binding Proteins Involved in the Regulation of Gene Expression
Dr. Jacqueline Anne Wilce, Assistant Professor, Department of Biochemistry & Molecular Biology, Monash University, Australia |
09:45-10:10 |
Title: Analyzing DNA-protein Interactions in Small Cell Numbers and Biopsies by Chromatin Immunoprecipitation
Dr. Philippe Collas, Professor of Medical Biochemistry, University of Oslo, Norway |
10:10-10:30 |
Coffee Break |
10:30-10:55 |
Title: Selectivity of Metal Ion Binding Specifically Drives the Interaction of a Ni2+-sensor with its Operator DNA
Dr. Barbara Zambelli, Research Associate, Agro-Environmental Science and Technology, University of Bologna, Italy |
10:55-11:20
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Title: Restriction-Modification Systems as Selfish Mobile Elements
Dr. Ichizo Kobayashi, Professor,University of Tokyo, Japan |
11:20-11:45 |
Title: Helicobacter Pylori Restriction Modification systems: Role beyond Genome Protection
Dr. Desirazu N Rao, Professor, Department of Biochemistry, IndianInstitute of Science, India |
11:45-12:10 |
Title: Character of Tumor Associated Protein Recognized by Monoclonal Antibody to Yunnan Gejiu Lung Cancer
Dr. Wang Qinqin, Director, Clinical Research Center, Kunming Medical college, China |
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Session 1-5: Structure Biology, Protein Structure, Dynamics and Functions (Part Ⅰ)
Time: March 22, 2010 13:30-17:30 |
Session Chair: |
Dr. Hao Wu, Professor of Biochemistry and Structural Biology, Department of Biochemistry , Weill Medical College of Cornell University, USA |
Co-Chair: |
Dr. Richard W. Kriwacki, Adjunct Associate Professor, Department of Structural Biology, St. Jude Children's Research Hospital, USA. |
13:30-13:55 |
Title: Asymmetric Interactions in Death Domain Oligomerization
Dr. Hao Wu, Professor of Biochemistry and Structural Biology, Department of Biochemistry, Weill Medical College of Cornell University, USA |
13:55-14:20 |
Title: Crystal Structures of Apo and Liganded Biotin Protein Ligase from Staphylococcus Aureus
Dr. Matthew Charles James Wilce, Head of Structural Biology, Monash University, Australia |
14:20-14:45 |
Title: Residue Structural Environment Descriptors and Fold Recognition
Dr. Malak Pirtskhalava, Head of the Department of Structural Bioinformatics, Institute of Molecular Biology and Biological Physics, Republic of Georgia |
14:45-15:10 |
Title: Role of Intrinsic Protein Flexibility in Regulatory Mechanisms
Dr. Richard W. Kriwacki, Adjunct Associate Professor, Department of Structural Biology, St. Jude Children's Research Hospital, USA |
15:10-15:30 |
Coffee Break |
15:30-15:55 |
Title: Computational Modelling of Protein Dynamics under External Stress
Dr. Irene Yarovsky, Professor, Discipline Head (Research)-Physics, School of Applied Sciences, RMIT University, Australia |
15:55-16:20 |
Title: Protein Supramolecules and Peptide Serving in Nanotechnology
Dr. Ichiro Yamashita, Professor, Nara Institute of Science and Technology, Japan |
16:20-16:45 |
Title: Thermodynamic and Biochemical Characteristics of Myoglobins from Aquatic Animals
Dr. Yoshihiro OCHIAI, Professor, Lab. Aquatic Bioscience, The University of Tokyo, Japan |
16:45-17:10 |
Title: S-layer Assembly
Dr. Seong-Ho Shin, Lawrence Berkeley National Laboratory, USA |
17:10-17:30 |
Panel Discussion |
|
Session 1-6: Membrane Proteins
Time: March 23, 2010 08:30-12:10 |
Session Chair |
Dr. Dirk Zimmermann, Global Development Lead, Assay & System Platform Program, Roche Diagnostics Ltd., Switzerland |
Co-Chair |
Dr. Jan Kubicek, QIAGEN GmbH, Germany |
08:30-08:50 |
Keynote Speaker:
Title: Membrane Proteins: From Atomic Structure to in Situ Arrangement
Dr. Werner Kuehlbrandt, Director, Department of Structural Biology, Max Planck Institute of Biophysics, Germany |
08:50-09:10 |
Title: Insights into Structure and Function of Membrane Transport Proteins by Protein Chemical and Electron Paramagnetic Resonance Spectroscopic Approaches
Dr. Heinrich Jung, Professor, Department of Biology I, Ludwig Maximilians University, Germany |
09:10-09:30 |
Title: Lipids as Topological Determinants of Membrane Proteins
Dr. William Dowhan, Professor, Department of Biochemistry & Molecular Biology, Medical School, University of Texas-Houston, USA |
09:30-09:50 |
Title: Stability of Membrane Proteins as Probed by High-Pressure Spectroscopy
Dr. Arvi Freiberg, Professor of Biophysics and Plant Physiology, University of Tartu, Estonia, Estonia |
09:50-10:10 |
Title: Electrofused Expressions Systems and Their Capability for Membrane Protein Characterisation Demonstrated by the Elucidation of the Molecular Properties of Channelrhodopsin-2
Dr. Dirk Zimmermann, Global Development Lead, Assay & System Platform Program, Roche Diagnostics Ltd., Switzerland |
10:10-10:30 |
Coffee Break |
10:30-10:50 |
Title: A New Method for Automated Crystallization of Membrane Proteins
Dr. Jan Kubicek, QIAGEN GmbH, Germany |
10:50-11:10 |
Title: Methods in Beta-barrel Membrane Protein Crystallization and the Structure of PorB from Neisseria Meningitidis
Dr. Tina Iverson, Assistant Professor of Pharmacology, Vanderbilt University, USA |
11:10-11:30 |
Title:AFM-based Investigations on the Interaction between Single Alpha-synuclein Peptides and Supported Lipid Bilayers
Dr. Frank W. S. Stetter, Department of Biophysics and Institute for Medical Engineering, Technical University of Munich, Germany |
11:30-11:50 |
Title: Membrane Protein Structure Prediction
Dr. William Bret Church, Department of Pharmaceutical Chemistry, University of Sydney, Australia |
11:50-12:10 |
Title: Peripheral Membrane Protein Structure and Function: Lessons from Phospholipase A2 and Lipoxygenase
Dr. Suren A. Tatulian, Department of Physics, University of Central Florida, USA |
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Session 1-7: Proteins and Signaling
Time: March 23, 2010 08:30-12:10 |
Session Chair |
Dr. Chris Proud, Professor, Human Genetics Division, University of Southampton, UK |
Co-Chair |
Dr. Xuemin Wang, Department of Biological Sciences, University of Southampton, UK |
08:30-08:55 |
Title: G Protein Coupled Receptors and Signaling in Hypothalamic GnRH Neurons
Dr. Lazar Krsmanovic, Staff Scientist, Section on Hormonal Regulation, PDEGEN, NICHD, NIH, USA |
08:55-09:20 |
Title: Regulation of G Protein Signaling by the 70kDa Heat Shock Protein
Dr. William Lim, Associate Professor, Faculty of Medicine and Health Sciences, University Malaysia Sarawak, Malaysia |
09:20-09:45 |
Title: Modulation of Choilnergic Receptor Signaling by Snake Neurotoxis
Dr. Yuri Utkin, Professor, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Russia |
09:45-10:10 |
Title: Small Molecules, Big Impacts: Quorum-Sensing Signaling in Bacterial Social Behaviors
Dr. Yung-Hua Li, Associate Professor, Dalhousie University, Canada |
10:10-10:30 |
Coffee Break |
10:30-10:55 |
Title: mTORC Signalling and the Regulation of Protein Synthesis
Dr. Xuemin Wang, Department of Biological Sciences, University of Southampton, UK |
10:55-11:20 |
Title: Quantitative Lipid Raft Proteomics of Caveolae and Non-Caveolar Caveolin-1
Dr. Michelle Hill, NHMRC Research Fellow, The University of Queensland, Australia |
11:20-12:10 |
Panel Discussion |
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Session 1-8: Protein Trafficking/ Transport/ Translocation, Assembly
Time: March 23, 2010 08:30-11:00 |
Session Chair: |
Dr. Wong Siew Heng, Assistant Professor, National University Health System, Singapore |
Co-Chair: |
Dr. J. David Van Horn, Assistant Professor of Chemistry, University of Missouri-Kansas City, USA |
08:30-08:50 |
Title: Different Roles for Chaperones and Scaffolds in GPCR Homo and Heterodimeric Receptor Complexes Assembly and Functions
Dr. Denis J. Dupré, Assistant Professor, Dalhousie University, Canada |
08:50-09:10 |
Title: Zonula Occludens Toxin and Its Derivatives Show Potential Success as Novel Absorption Enhancers Improving Drug Delivery
Dr. Noha Nabil Salama, Assistant Professor, Basic and Pharmaceutical Sciences, St. Louis College of Pharmacy, USA |
09:10-09:30 |
Title: Can Uranium Be Transported by the Iron Acquisition Pathways?
Dr. Miryana Hemadi, Assistant Professor, Department of Laboratoire ITODYS, Université Paris-Diderot – CNRS, France |
09:30-09:50 |
Title: Molecular Mechanism of Co-translational Protein Transport - a Tale of Two GTPases
Dr. Shu-ou Shan, Assistant Professor, California Institute of Technology, USA |
09:50-10:10 |
Title: Aggregation Mediated Sorting of Vacuolar Proteins into Transport Vesicles at the cis-Golgi Apparatus of Developing Plant Embryos
Dr. Giselbert Hinz, Department of Cell Biology, Heidelberg Institute for Plant Sciences, University of Heidelberg, Germany |
10:10-10:30 |
Title: ESCRT, Autophagy, and Frontotemporal Dementia
Dr. Jin-A Lee, Assistant Professor , College of Life Science and Nano Technology, Department of Biotechnology, Hannam University, Republic of Korea |
10:30-10:50 |
Title: Caspases Regulate Phagocytosis in Maturing Dendritic Cells
Dr. Wong Siew Heng, Assistant Professor, National University Health System, Singapore |
10:50-11:00 |
Coffee Break |
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Session 1-9: Protein Splicing and Endo-and Exocytosis
Time: March 23, 2010 11:00-12:10 |
Session Chair |
Dr. Wei Guo, Associate Professor of Biology, University of Pennsylvania, USA |
Co-Chair |
Dr. Debbie C. Thurmond, Associate Director, Herman B Wells Center for Pediatric Diabetes Research, Indiana University School of Medicine, USA |
11:00-11:20 |
Title: Molecular Machinery and Mechanisms Regulating Membrane Fusion
Dr. Thomas S?llner, Professor, Heidelberg University Biochemistry Center, Germany |
11:20-11:40 |
Title: Vesicle Exocytosis Mechanisms Gone Awry in Disease: New Insights into Old Mechanisms
Dr. Debbie C. Thurmond, Associate Director, Herman B Wells Center for Pediatric Diabetes Research, Indiana University School of Medicine, USA |
11:40-12:00 |
Title: The Exocyst Complex in Polarized Exocytosis
Dr. Wei Guo, Associate Professor of Biology, University of Pennsylvania, USA |
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Session 1-10: Protein Modifications and Metabolism
Time: March 23, 2010 13:30-17:30 |
Session Chair |
Dr. Birgit Kersten, Head of the GabiPD Team, Bioinformatics, Max Planck Institute for Molecular Plant Physiology, Germany |
Co-Chair |
Dr. Ganesh Kumar Agrawal, Associate Director, Research Laboratory for Biotechnology and Biochemistry (RLABB), Nepal |
13:30-13:55 |
Title: Detecting, Locating and Sequencing Protein Post-translational Modifications Using High Performance TOF Mass Spectrometry
Dr. James Langridge, Director Proteomics, Waters Corporation, UK |
13:55-14:20 |
Title: Proteome-wide Phosphorylation Patterns in Arabidopsis Thaliana and the Effect of Single Nuclear DNA Polymorphisms
Dr. Birgit Kersten, Head of the GabiPD Team, Bioinformatics, Max Planck Institute for Molecular Plant Physiology, Germany |
14:20-14:45 |
Title: Methylation of Lysines on Histone Tails: Implications for Gene Regulation and Developmental Biology
Dr. Reidunn Aalen, Professor, Department of Molecular Biosciences, University of Oslo, Norway |
14:45-15:10 |
Title: C. elegans CDC-48/p97 Controls Germline-specific Sex Determination
Dr. Kunitoshi Yamanaka, Associate Professor, Department of Molecular Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Japan |
15:10-15:30 |
Coffee Break |
15:30-15:55 |
Keynote Speech:
Title: Porosome: The Universal Secretory Machinery in Cells
Dr. Bhanu P. Jena, Associate Secretary General, International Federation of Cell Biology, George E. Palade University Professor & Distinguished Professor, Department of Physiology, Wayne State University School of Medicine; Director, NanoBioScience Institute, USA |
15:55-16:20 |
Title: Histone Purification in the Blink of an Eye from Whole and Undisturbed Cells While Preserving Histone Native Biomarkers
Dr. Pedro Rodriguez-Collazo, Research Assistant Professor, Cell Biology and Physiology, University of Pittsburgh, USA |
16:20-16:45 |
Title: Hypoxic Silencing of Tumor Suppressors by Epigenetic Mechanism in Cancer Progression
Dr. You Mie Lee, Associate Professor, Department of Natural Sciences, School of Life Sciences and Biotechnology, Kyungpook National University, Republic of Korea |
16:45-17:10 |
Title: How Can Enzymology Be Used for Agricultural Improvement Strategies
Dr. Stephen MG Duff, Senior Research Scientist, Monsanto, USA |
17:10-17:30 |
Title: Global In Vivo Phosphoproteomics of Developing Oilseed Discovers Extensive Phosphorylation in Metabolic Networks
Dr. Ganesh Kumar Agrawal, Associate Director, Research Laboratory for Biotechnology and Biochemistry (RLABB), Nepal |
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Session 1-11: Intrinsically Disordered Porteins
Time: March 23, 201013:30-17:30 |
Session Chair |
Dr. Peter Tompa, Group Leader, Hungarian Academy of Sciences, Hungary |
Co-Chair |
Dr. A. Keith Dunker, T-K Li Professor of Medical Research, Indiana University, Founder/Father of The Protein Trinity, USA |
13:30-13:55 |
Title: Structural Disorder and Viability of Aberrant Cellular Proteins
Dr. Peter Tompa, Group Leader, Hungarian Academy of Sciences, Hungary |
13:55-14:20 |
Title: Prediction of Disordered Proteins and Disordered Binding Regions
Dr. Zsuzsanna Dosztányi, Senior Scientist, Institute of Enzymology, BRC, Hungarian Academy of Sciences, Hungary |
14:20-14:45 |
Title: Structural Stability and Functional Remodeling of Plasma Lipoproteins: Functional Role of Structural Disorder
Dr. Olga Gursky, Associate Professor, Physiology and Biophysics
Boston University School of Medicine, USA |
14:45-15:10 |
Title: Origin of the Enhanced Binding Rates for Intrinsically Disordered Proteins
Dr. Zhirong Liu, Associate Professor, College of Chemistry and Molecular Engineering, Peking University, China |
15:10-15:30 |
Coffee Break |
15:30-15:55 |
Title: Pup, a Prokaryotic Ubiquitin-like Protein, is an Intrinsically Disordered Protein
Dr. Xiaoming Tu, Associate Professor, School of Life Sciences, University of Science and Technology of China, China |
15:55-16:20 |
Title: The EWS Family of Oncoproteins: Uncovering the Hidden Structure
Dr. Kevin A. W. Lee, Associate Professor, Department of Biology, Hong Kong University of Science and Technology, China |
16:20-16:45 |
Title: Development of an Order/Disorder Assignment Method for Protein Molecules and its Application to the Human Proteome
Dr. Ken Nishikawa, Professor,Department of Bioinformatics, Maebashi Institute of Technology, Japan |
16:45-17:10 |
Title: NMR Delineation of Pre-Structured Motifs(PreSMos)in Intrinsically Unfolded Proteins(IUPs)
Dr. Kyou-Hoon Han, Senior Investigator,KRIBB, Korea |
17:10-17:30 |
Panel Discussion |
|
Session 1-12: Structure Biology, Protein Structure, Dynamics and Functions (Part Ⅱ)
Time: March 23, 2010 13:30-17:30 |
Session Chair |
Dr. Maria Celeste Sagui, Professor, Department of Physics, North Carolina State University, USA |
Co-Chair |
Dr. Wei Feng, Professor, Institute of Biophysics, Chinese Academy of Sciences, China |
13:30-13:55 |
Title: Structural Biology and Inhibition of Enzymes that Assemble Outer Membrane lipids in E. coli: Targets for New Antibiotics
Dr. Christian R. H. Raetz, George Barth Geller Professor, Department of Biochemistry, Duke University Medical Center; Member, National Academy of Sciences of the United States of America, USA |
13:55-14:20 |
Title: Calculating Free Energy Landscapes of Helix-Forming Peptides Using An Adaptively Biased Molecular Dynamics Method
Dr. Maria Celeste Sagui, Professor, Department of Physics, North Carolina State University, USA |
14:20-14:45 |
Title: Quantifying Conformational Flexibility and Dynamics in Protein Families
Dr. Andrew J. Rader, Assistant Professor, Department of Physics, Indiana University-Purdue University Indianapolis, USA |
14:45-15:10 |
Title: Myosin VI Undergoes Cargo-Mediated Dimerization
Dr. Wei Feng, Professor, Institute of Biophysics, Chinese Academy of Sciences, China |
15:10-15:30 |
Coffee Break |
15:30-15:55 |
Title: Molecular Dynamics of Human Serum Albumin Complexed with Fatty Acids
Dr. Bruno Rizzuti, Associate Researcher, LiCryL INFM-CNR, Cemif.Cal , National Council of Research, Italy |
15:55-16:20 |
Title: Evolution, Function and Structure of Leucine-rich Repeats
Dr. Norio Matsushima, Professor, Sapporo Medical University, Japan |
16:20-16:45 |
Title: Distill, Protein Structure Prediction by Machine Learning
Dr. Gianluca Pollastri, School of Computer Science and Informatics and Complex and Adaptive Systems Labs, University College Dublin, Ireland |
16:45-17:10 |
Title: Nature of Inter-NBD (Nucleotide Binding Domain) Communication in P-Glycoprotein, a Multi Drug Efflux Pump
Dr. S.L.N. Prasad Reddy, Pharmaceutical Biotechnology, Samskruti College of Pharmacy, India |
17:10-17:30 |
Panel Discussion |
|
|
Symposium 2: Protein Technologies
Session 2-1: Protein Screening, Bioassay and Discovery
Time: March 21, 2010 13:30-15:30 |
Chair |
Dr. Jens R. Coorssen, Foundation Chair & Head, Molecular Physiology and the Molecular Medicine Program, University of Western Sydney, Australia |
13:30-13:55 |
Title: A High Throughput Protein Binding Assay Based on Protein Stability
Dr. Yi Wang, Chief Scientific Officer, Pharmadiscover Inc., China |
13:55-14:20 |
Title: Refining Gel-based Proteomics to Optimize Analyses
Dr. Jens R. Coorssen, Foundation Chair & Head, Molecular Physiology and the Molecular Medicine Program, University of Western Sydney, Australia |
14:20-14:45 |
Title: Synthetic Peptide Based in Vitro Assay for Food Borne Toxins Detection as an Alternative to Animal Bioassay
Dr. Reuven Rasooly, Research Chemist, United States Department of Agriculture, USA |
14:45-15:10 |
Title: Identification of Food-Derived Peptides in Human Peripheral Blood -Good Candidate for Active Peptide with Health-Promotion Activity
Dr. Kenji Sato, Professor, Kyoto Prefectural University, Japan |
15:10-15:30 |
Coffee Break |
|
Session 2-2: Protein Chips, Arrays and Protein Structures in Silico
Time: March 21, 2010 15:30-17:30 |
Session Chair: |
Dr. Anthony R. White, Head, The University of Melbourne, Australia |
15:30-15:55 |
Title: Microfluidics, Multiplexing and Workflow Integration for Next Generation Protein Analysis Platforms
Dr. Thomas Li, Senior Director, Technology Management, Chief Technology Office, Roche Diagnostics, USA |
15:55-16:20 |
Title: Investigating Metal-regulated Protein Expression Using Antibody Microarrays and Protein-protein Interaction Database Analysis
Dr. Anthony R. White, Head, The University of Melbourne, Australia |
16:20-16:45 |
Title: The Use of Amphipathic Polymers ('Amphipols') to Fold, Keep Soluble and Stabilize Membrane Proteins, and to Immobilize them onto Solid Supports
Dr. Jean-Luc. POPOT, Director, CNRS/University Paris 7, France |
16:45-17:10 |
Title: Biomolecules Array on Chip Using 2D Chemicla Modification of Self-assembly Monolayer
Dr. Atsushi Kira, Supervisor, ULVAC Inc., Japan |
17:10-17:30 |
Panel Discussion |
|
Session 2-3: NMR, EM and X-Ray Crystallography
Time: March 22, 2010 08:30-12:10 |
Session Chair: |
Dr. Ingeborg Schmidt-Krey, Professor, Georgia Institute of Technology, USA |
Co-Chair: |
Dr. Akira Naito, Professor, Yokohama National University, Japan |
08:30-08:55 |
Title: Efficient Studies of Protein-protein Interactions by NMR Spectroscopy
Dr. Gerhard Wider, Director of High Field NMR Laboratory, Swiss Federal Institute of Technology ETH Zurich, Switzerland |
08:55-09:20 |
Title: Use of High Throughput Diffraction Capable Nanofluidic Chip in Protein Crystallization Screening and Hands-free X-ray Data Collection
Dr. Hazelle Lam, Director, Fluidigm Corporation, USA |
09:20-09:45 |
Title: Structure-Function Studies of the Membrane Protein Human Leukotriene C4 Synthase by Cryo-EM
Dr. Ingeborg Schmidt-Krey, Professor, Georgia Institute of Technology, USA |
09:45-10:10 |
Title: Dissecting the Three-dimensional Structure of the Power-generating Mechanism of the Bacterial Flagellar Motor
Dr. Anna Roujeinikova, Associate Professor, Monash University, Australia |
10:10-10:30 |
Coffee Break |
10:30-10:55 |
Title: Purification and NMR Structural Characterization of Bovine Antimicrobial Peptide, Lactophoricin
Dr. Yongae Kim, Professor, Hankuk University of Foreign Studies, Republic of Korea |
10:55-11:20 |
Title: Structure Elucidation of Membrane-associated Peptides and Proteins Bound to Lipid Bilayers as Revealed by Solid-state NMR Spectroscopy
Dr. Akira Naito, Professor, Yokohama National University, Japan |
11:20-11:45 |
Title: NMR Experiments on Drug Candidates for the Sin3 Corepressor Bound to the Neural Repressor NRSF/REST Related to Meduloblastoma
Dr. Yoshifumi Nishimura, Professor, Yokohama City University, Japan |
11:45-12:10 |
Title: Structural Biology of Disease Related Proteoglycans by NMR and X-ray Crystallography
Dr. Weontae Lee, Professor & Chairman, Yonsei University, South Korea |
|
Session 2-4: Cell Free Technologies for Proteins
Time: March 22, 2010 13:30-15:50 |
Session Chair: |
Dr. Yaeta Endo, Professor & Director, Cell-Free Science and Technology Research Center, Ehime University, Japan |
13:30-13:50 |
Keynote Speaker
Title: Advances in the Cell-Free Protein Production for Postgenome Sciences
Dr. Yaeta Endo, Professor & Director, Cell-Free Science and Technology Research Center, Ehime University, Japan |
13:50-14:10 |
Title: Synthesis of A Rtificially-functionalized Peptides Using Cell-free Translation Agoyaand in Vitro Selection Method
Dr. Akira Wada, Research Scientist, Advanced Science Institute, RIKEN, Japan |
14:10-14:30 |
Title: Isolation Technique and New Functions of Cell-free Protein in the Formation of Single Crystals in Calcified Endoskeleton
Dr. M. Azizur Rahman, Associate Professor, University of the Ryukyus, Japan |
14:30-14:50 |
Title: Cell-free Protein Synthesis at High Temperatures Using the Lysate of a Hyperthermophile
Dr. Tamotsu Kanai, Assistant Professor, Kyoto University, Japan |
14:50-15：10 |
Title: Cell-free Synthesis of the Torque Generating Bacterial Flagellar Motor Proteins
Dr. Seiji Kojima, Assistant Professor, Nagoya University, Japan |
15:10-15:30 |
Title: PURE System for Production and Creation of Biosystems in Vitro
Dr. Takuya Ueda, Professor, Department of Medical Genome Sciences, The University of Tokyo, Japan |
15:30-15:50 |
Coffee Break |
|
Session 2-5: Protein Separation and Purification Technologies
Time: March 22, 2010 15:50-17:30 |
Session Chair: |
Dr. Yaeta Endo, Professor & Director, Cell-Free Science and Technology Research Center, Ehime University, Japan |
15:50-16:10 |
Title: In-Depth Analysis of Serum by Consecutive Depletion and Multi-Dimensional De-Complexing Followed by Nano-LC-MS/MS
Dr. Manfred Raida, Group Leader, Experimental Therapeutics Centre, Singapore |
16:10-16:30 |
Title: Discovery of Novel Calcium Oxalate Crystal Growth Inhibitory Proteins from Medicinal Plants by Mass Spectrometry
Dr. Chanderdeep Tandon, Associate Professor, Jaypee University of Information Technology, India |
16:30-16:50 |
Title: SFO Ultrasonic Assisted Enzymolysis of Wheat Germ for Preparation of the ACE Inhibiting Peptide and its Reaction Kinetics
Dr. Haile Ma, Professor, School of Food and Biological Engineering, Jiangsu University, China |
16:50-17:10 |
Title: Development of Novel Synthetic Hydrophilic Resin for Drug-protein Interaction Analysis
Dr. Takao Isogai, Professor, The University of Tokyo, Japan |
17:10-17:30 |
Title: Improving Recombinant Protein Purification Yield
Dr. Heping Cao, Principal Research Scientist, United States Department of Agriculture, USA |
|
Symposium 3: Proteins and Diseases
Session 3-1: Protein Interactions and Diseases
Time: March 21, 2010 13:30-17:30 |
Session Chair: |
Dr. Suk-Hwan Baek, Professor, Youngnam University, South Korea |
Co-Chair: |
Dr. Lian Li, Professor and Vice Chair, Emory University, USA |
13:30-13:55 |
Title: Alpha-synuclein and its A30P Mutant Affect Actin Cytoskeletal Structure and Dynamics
Dr. Evelina Chieregatti, Team Leader, The Italian Institute of Technology, Italy |
13:55-14:20 |
Title: Parkin-Mediated Ubiquitin Signaling and Parkinson Disease
Dr. Lian Li, Professor and Vice Chair, Emory University, USA |
14:20-14:45 |
Title: The Role of Small Heat Shock Proteins in Amyloid Fibril-associated Diseases
Dr. Heath Ecroyd, University of Wollongong, Australia |
14:45-15:10 |
Title: The Interaction of ERK1/2 with Gbetagamma Subunits Triggers the Function of ERK1/2 towards Cardiac Hypertrophy
Dr. Kristina Lorenz, Institute of Pharmacology and Toxicology, University of Würzburg, Germany |
15:10-15:30 |
Coffee Break |
15:30-15:55 |
Title: Role of NADPH Oxidase 1 in Toll-Like Receptor-Mediated Atherosclerosis
Dr. Suk-Hwan Baek, Professor, Yeungnam University, South Korea |
15:55-16:20 |
Title: Are Proprotein Convertases Therapeutic Targets for Prevention of Malignant Progression of MGUS?
Dr. Alphons Vermorken, Professor, University of Leuven, Belgium |
16:20-16:45 |
Title: Novel Self-association of the APC Molecule Affects APC Clusters and Cell Migration
Dr. Zhuoyu Li, Professor, Shanxi University , China |
16:45-17:10 |
Title: Molecular and Cellular Dysfunction of Spinocerebellar Ataxia Type 1 (SCA1) Disease
Dr. Sunghoi Hong, Associate Professor, Korea University,South Korea |
17:10-17:30 |
Title: Protein-protein Interaction and Disease
Dr. Zhen-Lin Wang, Professor, Xi'an Jiaotong University, China
|
|
Session 3-2: Protein Networks in Disease
Time: March 21, 2010 16:00-17:20 |
Session Chair: |
Dr. Celia R. S. Garcia, Professor, University of Sao Paulo, Brazil |
16:00-16:20 |
Title: Analysis on Drug Interactions in Biochemical Networks
Dr. Jose C. Nacher, Associate Professor, Future University Hakodate, Japan |
16:20-16:40 |
Title: Dissecting Protein Signaling Network in Malaria Parasites
Dr. Celia R. S. Garcia, Professor, University of Sao Paulo, Brazil |
16:40-17:00 |
Title: Molecular Mechanism of RecQ Helicase Function in Human Cancers and Premature Aging Diseases
Dr. Jin-Shan Hu, Associate Professor, Department of Basic Medical Sciences, Western University of Health Sciences, USA |
17:00-17:20 |
Title: Expression and Regulation of Heat Shock Protein 70 During Chemical Anoxia in Fish and Mouse Cells.
Dr. Carlo Gunnar Ossum, Scholar, University of Copenhagen, Denmark |
|
Session 3-3: Proteins in Apoptosis and Autophagy
Time: March 22, 2010 08:30-10:55 |
Session Chair: |
Dr. Shazib Pervaiz, Professor, National University of Singapore, Singapore |
08:30-08:50 |
Title: Induction of Autophagy by Anthrax Lethal Toxin
Dr. Aiguo Wu, Vice President, AFG Biosolutions Inc., USA |
08:50-09:10 |
Title: Cancer Cell Mitochondrial Metabolism and the Anti-apoptotic Protein Bcl-2
Dr. Shazib Pervaiz, Professor, National University of Singapore, Singapore |
09:10-09:30 |
Title: Apaf-1 Function in Chemoresistant Ovarian Cancer
Dr. J. Rebecca Liu, Associate Professor, University of Michigan Comprehensive Cancer Center, USA |
09:30-09:50 |
Title: SET/I2PP2A Localization and Cell Death
Dr. Bernadette Allinquant, Research Director, Université Paris-Descartes, France |
09:50-10:10 |
Title: Selective Turnover of p62 by Autophagy
Dr. Yoshinobu Ichimura, Assistant Professor, Juntendo University School of Medicine, Japan |
10:10-10:30 |
Title: Autophagy in Development and Remodeling of Mammary Gland
Dr. Malgorzata Gajewska, Warsaw University of Life Sciences, Poland |
10:30-10:50 |
Title: Molecular Mechanisms of GNA-related Lectin-induced Apoptosis and Autophagy in Cancer Cells
Dr. Bo Liu, Lecturer, Sichuan University, China |
10:50-10:55 |
Coffee Break |
|
Session 3-4: Protein Misfolding and Cancers
Time: March 22, 2010 10:55-12:15 |
Session Chair: |
Dr. Shazib Pervaiz, Professor, National University of Singapore, Singapore |
10:55-11:15 |
Title: Towards Targeting the Unfolded Protein Response in Human Melanoma
Dr. Xu Dong Zhang, Conjoint Professor, Calvary Mater Newcastle Hospital, Australia |
11:15-11:35 |
Title: Fourier Transform Infrared Spectroscopy to Monitor Protein Misfolding and Aggregation.
Dr. Silvia Maria Doglia, Professor, Department of Biotechnology and Biosciences, University of Milano Bicocca, Italy |
11:35-11:55 |
Title: A Model of Amyloid’s Role in Disease Based on Fibril Fracture
Dr. Damien Hall, Assistant Professor, University of Tsukuba, Japan |
11:55-12:15 |
Title: Endoplasmic Reticulum Stress as a Progression Factor for Kidney Disease
Dr. Reiko Inagi, Senior Researcher, University of Tokyo School of Medicine, Japan |
|
Session 3-5: Protein Misfolding and Neurodegeneration
Time: March 22, 2010 13:30-17:30 |
Session Chair: |
Dr. Christian Griesinger, Professor, The Max Planck Institute for Biophysical Chemistry, Germany |
Co-Chair: |
Dr. Alfred Stracher, Chairman, Distinguished Professor of Biochemistry, State University of New York Downstate Medical Center at Brooklyn, USA |
13:30-13:55 |
Keynote Speaker:
Title: Calpain Inhibition to Treat Neurodegeneartive Diseases
Dr. Alfred Stracher, Chairman, Distinguished Professor of Biochemistry, State University of New York Downstate Medical Center at Brooklyn, USA |
13:55-14:20 |
Title: Polyglutamine Protein Misfolding and Neurodegeneration
Dr. Xiao Jiang Li, Distinguished Professor, Emory University School of Medicine, USA |
14:20-14:45 |
Title: The Mitigation of Protein Misfolding by Molecular Chaperone Proteins
Dr. John Carver, Professor, School of Chemistry & Physics, The University of Adelaide, Australia |
14:45-15:10 |
Title: Novel Calpain Inhibitors Protect Against the Neuropathologic Sequelae of Traumatic Brain Injury
Dr. Douglas S. F. Ling, Associate Professor, SUNY Downstate Medical Center, USA |
15:10-15:30 |
Coffee Break |
15:30-15:55 |
Title: Cdk5 and Neuron Cell Death
Dr. Shin-ichi Hisanaga, Professor, Tokyo Metropolitan University, Japan |
15:55-16:20 |
Title: A Novel Protease (Calpain) Inhibitor for the Treatment of Neurodegenerative Diseases
Dr. Getaw Hassen, Post-doctoral Fellow & Clinical Instructor , SUNY Downstate Medical Center, USA |
16:20-16:45 |
Title: Structural Polymorphism of Tau Filaments
Dr. Martin Margittai, Assistant Professor, Department of Chemistry and Biochemistry, University of Denver, USA |
16:45-17:10 |
Title: New Trends in the Evolving Role of Unstructured Proteins in the Etiology of Distinct Human Diseases
Dr. Ferenc Orosz, Senior Researcher, Hungarian Academy of Sciences, Hungary |
17:10-17:30 |
Title: Regulation by Protein Phosphorylation in Bacterial Signal Transduction Systems
Dr. Jeffry B. Stock, Departments of Molecular Biology and Chemistry, Princeton University, USA |
Session 3-6: Protein Therapeutics for Immunologic & Inflammatory Diseases
Time: March 23, 2010 08:30-12:10 |
Session Chair: |
Dr. Yoshinori Mine, Professor, University of Guelph, Canada |
Co-Chair: |
Dr. Fang Yan, Visiting Professor, Tianjin Medical University, China |
08:30-09:00 |
Title: Dietary Peptide-based Intervention to Improve Chronic Inflammation
Dr. Yoshinori Mine, Professor, University of Guelph, Canada |
09:00-09:30 |
Title: Benefits of Oral Epidermal Growth Factor to Gut Health: A New Blockbuster?
Dr. Andre G. Buret, Professor and Chair, University of Calgary, Canada |
09:30-10:00 |
Title: Regulatory Roles of Amino Acids and Proteins in Immune Response of Inflammatory Bowel Disease
Dr. Maiko Mori, Senior Scientist, Exploratory & Applied Pharmaceutical Research Department, Ajinomoto Co., Inc., Japan |
10:00-10:20 |
Coffee Break |
10:20-10:50 |
Title: Lactobacillus Rhamnosus GG-derived Soluble Proteins Prevent Intestinal Inflammation Through Activation of Epidermal Growth Factor Receptor Signaling Pathway
Dr. Fang Yan, Visiting Professor, Tianjin Medical University, China |
10:50-11:20 |
Title: Binding Mode and Selectivity of Endotoxin Variants
Dr. Monique Sylvie Gangloff, Research Associate, University of Cambridge, UK |
11:20-12:10 |
Panel Discussion |
|
|
Symposium 4: Human Proteome Technologies and Cancer Research
Session 4-1: MS, Imaging MS and MALDI-TOF in Proteomics
Time: March 21, 2010 13:30-16:00 |
Session Chair |
Dr. J. Sabine Becker, Head of Trace and Ultratrace Analysis, Central Division of Analytical Chemistry, Germany |
Co-Chair |
Dr. Michael Sefkow, Head of Chemical Synthesis, Caprotec Bioanalytics GmbH, Germany |
13:30-13:50 |
Keynote Speaker:
Title: New Directions in Bioimaging Mass Spectrometry and Metallomics for Neurosciences
Dr. J. Sabine Becker, Head of Trace and Ultratrace Analysis, Central Division of Analytical Chemistry, Germany |
13:50-14:10 |
Title: Capture Compound Mass Spectrometry – an Novel Platform Technology for Functional Proteomics
Dr. Michael Sefkow, Head of Chemical Synthesis, Caprotec Bioanalytics GmbH, Germany |
14:10-14:30 |
Title: Multi Modality Imaging with Diversity Oriented Fluorescence Library Approach and MS Spectrometry
Dr. Chang Young-Tae, Associate Professor, National University of Singapore, Singapore |
14:30-14:50 |
Title: Discovery of Potential Tumor-associated Biomarkers in Human Thyroid and Kidney Carcinoma by Imaging Mass Spectrometry
Dr. Kwang Pyo Kim, Associate Professor, Konkuk University, Republic of Korea |
14:50-15:10 |
Title: Protein N- and C-Termini Identification Using Mass Spectrometry and Isotopic Labeling
Dr. Bosong Xiang, Senior Scientist, Monsanto Company, USA |
15:10-15:30 |
Title: TOF-SIMS Imaging of Biological Tissues
Dr. Olivier Laprévote, Team Leader, Institute of Natural Products Chemistry, France |
15:30-15:50 |
Title: Interactions of Metal-Based Anticancer Complexes with Albumin
Dr. Fuyi Wang, Professor, Institute of Chemistry, Chinese Academy of Sciences, China |
15:50-16:00 |
Coffee Break |
|
Session 4-2: Computational Proteomics and Bioinformatics
Time: March 22, 2010 08:30-10:30 |
Session Chair |
Dr. Scott Ely, Co-Director, Section of Hematopathology, Department of Pathology, Weill Medical College of Cornell University, New York Presbyterian Hospital, USA |
Co-Chair |
Dr. Shawn SC Li, Associate Professor, University of Western Ontario, Canada |
08:30-08:50 |
Title: Efficient Web-Browsing for the Life-Scientist
Dr. Reinhard Schneider, Team Leader, the EMBL Heidelberg, Data Integration and Knowledge Management, Germany |
08:50-09:10 |
Title: Searching for Amyloid Conformations of Transthyretin with the Help of Unfolding Simulations and Bioinformatics Tools
Dr. Rui M. Brito, Centre for Neurosciences and Cell Biology and Chemistry Department, Universidade de Coimbra, Portugal |
09:10-09:30 |
Title: Localized Network Centrality and Essentiality in the Yeast–Protein Interaction Network
Dr. Dongsup Kim, Associate Professor, Department of Bio and Brain Engineering, KAIST, Republic of Korea |
09:30-09:50 |
Title: Proteomic Database of the Agarose 2-DE for High-Molecular-Mass (>200kDa) Proteins
Dr. Masamichi Oh-Ishi, Associate Professor, Department of Physics, Kitasato University School of Science, Japan |
09:50-10:10 |
Title: The Community Structure of Human Cellular Signaling Network
Dr. Yuanbo Diao, Lecturer, College of Chemistry, Sichuan University, China |
10:10-10:30 |
Coffee Break |
|
Session 4-3: Nanoproteomics, Chip and Array Technologies in Proteomics
Time: March 22, 2010 10:30-12:10 |
Session Chair |
Dr. Scott Ely, Co-Director, Section of Hematopathology, Department of Pathology, Weill Medical College of Cornell University, New York Presbyterian Hospital, USA |
Co-Chair |
Dr. Shawn SC Li, Associate Professor, University of Western Ontario, Canada |
10:30-10:50 |
Title: A Method for Cancer Cell-Specific Protein Detection at the Single Cell Level
Dr. Scott Ely, Co-Director, Section of Hematopathology, Department of Pathology, Weill Medical College of Cornell University, New York Presbyterian Hospital, USA |
10:50-11:10 |
Title: Mapping Phosphotyrosine Signaling Network by Peptide and Protein Arrays
Dr. Shawn SC Li, Associate Professor, University of Western Ontario, Canada |
11:10-11:30 |
Title: Functional Proteomics Approach for Understanding Salinity Tolerance: Lessons From the Halotolerant Alga Dunaliella Salina
Dr. Katz Adriana, Associate Staff Scientist, Department of Biological Chemistry, Weizmann Institute of Science, Israel |
11:30-11:50 |
Title: Newly Designed Fluorescent Protein Probes and Application to Fully Automated 2D Electrophoresis System
Dr. Kenji Yokoyama, Deputy Director, Biotechnology Industrialization Center, National Institute of Advanced Industrial Science and Technology, Japan |
11:50-12:10 |
Title: Multivalent Chelators: Versatile Tools for Probing Protein Functions at Interfaces
Dr. Changjiang You, Group Leader, Biology University of Osnabrück, Germany |
|
Session 4-4: Proteome Technologies and Breast Cancer, Colorectal and Colon Cancer
Time: March 22, 2010 13:30-17:30 |
Session Chair |
Dr. E.L. Iorio, President, International Observatory of Oxidative Stress, Italy |
13:30-13:50 |
The: Novel Field of Redoxomics
Dr. E.L. Iorio, President, International Observatory of Oxidative Stress, Italy |
13:50-14:10 |
Title: Interrogation of the Colon Mitoproteome: Links with Obesity Related Cancer
Dr. Janice Elizabeth Drew, Principal Investigator, Molecular Signalling Laboratory, Gut Health Department, Rowett Institute of Nutrition and Health, University of Aberdeen, Scotland |
14:10-14:30 |
Title: The Role of Kallikrein-Related Peptidases in Colorectal Cancer
Dr. Maroulio Talieri, Director, the Department of Cellular Physiology, "Saint Savas" Hospital, Greece |
14:30-14:50 |
Title: Profiling Stress Proteome of Lactic Acid Bacteria
Dr. Ozlem OSMANAGAOGLU, Associate Professor, Department of Biology, Ankara University, Turkey |
14:50-15:10 |
Title: The Role and Regulation of Eukaryotic Translation Initiation Factor 5A2 (eIF5A2) in Liver Cancer and Implications for Treatment
Dr. Nikki P. Lee, Research Assistant Professor, Surgery, The University of Hong Kong, Hong Kong, China |
15:10-15:30 |
Coffee Break |
15:30-15:50 |
Title: Fluorescent Immunoprecipitation Assay as a Methodology for Profiling of Cell Membrane Protein Complexes
Dr. Grigory Ivanovich Krotov, Senior Researcher, Antidoping Centre Moscow, Russia |
15:50-16:10 |
Title: High Through-put Proteomic Tools for Cancer Biomarker Discovery
Dr. Donghui Ma, OriGene Technologies Inc., USA |
16:10-16:30 |
Title: Approach to Discover Screening Biomarker in Breast Cancer
Dr. Dong-Young Noh, Professor of Department of Surgery, Chief of Comprehensive Cancer Center, Seoul National University & Seoul National University Hospital, Republic of Korea |
16:30-16:50 |
Title: Molecular Classification of Breast Cancer and Role of Immunohistochemistry for Detection of Cell Types that Predicts Response to Chemotherapy with Santinib (P53)
Dr. Mulazim Hussain Bukhari, Associate Professor, King Edward Medical Universiity, Pakistan |
16:50-17:10 |
Title: The Bottlenecks and Solutions to High-throughput Protein Research Technology
Mr. Lei Li, Product Specialist, Marketing, Gene Company Limited, China |
17:10-17:30 |
Panel Discussion |
|
Session 4-5: Proteomics of Lung Cancer, Esophageal Cancer, Leukemia, Ovarian and Cervical Cancer
Time: March 23, 2010 13:30-15:30 |
Session Chair |
Dr. Marika Crohns, Specialist in Oncology and Radiotherapy, University of Tampere, Finland |
Co-Chair |
Dr. Qun Zhao, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, China |
13:30-13:50 |
Title: Cytokines before and during Radiotherapy for Lung Cancer- Relationship of IL-8 and VEGF with Survival
Dr. Marika Crohns, Specialist in Oncology and Radiotherapy, University of Tampere, Finland |
13:50-14:10 |
Title: Regulation of Cancer by Therapeutic Vaccination and Dietary Bio-modulation Involving Organ Specific Mitochondria
Dr. Faik Atroshi , Pharmacology & Toxicology, 00014 University of Helsinki, Finland |
14:10-14:30 |
Title: Role of 3q26.2 Dysregulated Genes in Ovarian Cancer Development
Dr. Meera Nanjundan, Assistant Professor, Department of Cell Biology, Microbiology and Molecular Biology (CMMB), USA |
14:30-14:50 |
Title: High Molecular Weight Complex in Leukemia
Dr. Elena Puccetti, Junior Group Leader, Institute for Molecular Biology and Tumor Research (IMT), Germany |
14:50-15:10 |
Title: Proteomic-based Approach Identifying Autoantibody as a Novel
Serum Marker in Esophageal Squamous Cell Carcinoma
Dr. Yoshihisa Fujita, Assistant Professor, Department of General and Gastroenterological Surgery,
Osaka Medical College, Japan |
15:10-15:30 |
Title: Development of Proteomics in Human Cervical and Ovarian Cancer Research
Dr. Qun Zhao, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, China |
|
Session 4-6: Proteomics of Hepatic and Pancreatic Cancer
Time: March 23, 2010 15:30-17:50 |
Session Chair |
Dr. Hwyda A. Arafat, Associate Professor, Co-Director, Department of Surgery, Pathology Anatomy and Cell Biology, Jefferson Medical College, USA |
Co-Chair |
Dr. Eyyad Hassan A Kamel, Director, Department of Alternative Medicine, Mushfa Research Center, Kingdom Saudi Arabia |
15:30-15:50 |
Keynote Speaker:
Title: Blood-based Exopeptidase Activities as Biomarkers for Prostate Cancer
Dr. Paul Tempst, Professor and Director of Proteomics, Molecular Biology, Memorial Sloan-Kettering Cancer Center, USA |
15:50-16:10 |
Title: Distinctive Changes in Serum Proteins Associated with Chronic Pancreatitis, Autoimmune Pancreatitis and Pancreatic Cancer: Identification of Potential Biomarkers
Dr. Klaus Felix, Research Group Leader, Department of General Surgery, University of Heidelberg, Germany |
16:10-16:30 |
Title: Expression and Roles of FGFR2 Isoforms in Pancreatic Cancer Cells
Dr. Toshiyuki Ishiwata, Associate Professor, Department of Pathology, Integrative Oncological Pathology, Nippon Medical School, Japan |
16:30-16:50 |
Title: Cymetiron (Hepron-BM) as Initial Treatment for Chronic Hepatitis C
Dr. Eyyad Hassan A Kamel, Director, Department of Alternative Medicine, Mushfa Research Center, Kingdom Saudi Arabia |
16:50-17:10 |
Title: Osteopotnin Isoform (OPNc): a Potential Marker in Pancreatic Ductal Adenocarcinoma
Dr. Hwyda A. Arafat, Associate Professor, Co-director, Department of Surgery, Pathology Anatomy and Cell Biology, Jefferson Medical College, USA |
17:10-17:30 |
Title: Anti-tumor Activities of Histone Deacetylase Inhibitors Against Various Cancers
Dr. Takashi Kumagai, Director of Hematology, Ohme Municipal General Hospital, Clinical Asscociate Professor of Medicine, Tokyo Medical and Dental University, Japan |
17:30-17:50 |
Title: Phosphoproteomics Exploration Reveals that FER Non-Receptor Tyrosine Kinase Plays a Regulative Role in the Metastasis of Hepatocellular Carcinoma Cell
Dr. Haiyu Li, Instructor, Biochemistry & Molecular Biology, Shaoxing University, China |
|
Symposium 5: Protein Kinases
Session 5-1: Protein Kinases and Kinome as Drug Targets-Preclinical to Clinical Trials
Time: March 21, 201013:30- 15:00 |
Session Chair |
Dr. Zhaohua Irene Tang, Associate Professor of Biology, Claremont Colleges, USA |
13:30-13:50 |
Keynote Speaker:
Title: Functional Interrogation of the Kinome in Drug Discovery
Dr. John W. Kozarich, Chairman & President, ActivX Biosciences, Inc.; Chief Scientific Advisor, Kyorin Pharmaceutical Co., LTD., USA |
13:50-14:10 |
Title: RAS-activated Kinases as Potential Anti-invasion Drug Targets in Cancer and Development of a New Chemical-genetic Platform for Rapid Generation of Specific Inhibitors of these and other Kinases
Dr. Morten Frödin, Group leader, Biotech Research and Innovation Centre, University of Copenhagen, Denmark |
14:10-14:30 |
Title: Systematic Analysis of Response Pathways to Phenol Derivatives as Environmental Factors at the Kinomic and Genomic Sales
Dr. Zhaohua Irene Tang, Associate Professor of Biology, Claremont Colleges, USA |
14:30-14:50 |
Title: Molecular Dynamics Simulations Suggest a Molecular-level Oncogenesis Mechanism Shared by Several Cancer Mutants of the EGF Receptor Kinase
Dr. Yibing Shan, D.E. Shaw Research, USA |
14:50-15:00 |
Coffee Break |
|
Session 5-2: Protein Kinase and Apoptosis
Time: March 21, 2010 15:00- 17:20 |
Session Chair |
Dr. Charles J. Malemud, Professor, Case Western Reserve University School of Medicine, USA |
15:00-15:20 |
Keynote Speaker:
Title: A New Point of Control of Apoptosis by C-abl: the Mitochondrial Proteins Mtaxin 1
Dr. Francois Vallette, Director of Research INSERM (French National Institute of Health and Medical Research); Director of team 9 "apoptosis and tumor progression",Cancer Research Center of Nantes Angers, University of Nantes, France |
15:20-15:40 |
Title: Death-Associated Protein Kinases (DAPKs) Inhibitors
Ms. Masako Okamoto, Senior Scientist, Research & Development Division, PharmaDesign, Inc., Japan |
15:40-16:00 |
Title: Post-translational Modifications Switch theFunctional of l Human Ribosomal Protein S3 in DNA Repair and Translation
Dr. Joon Kim, Professor, Laboratory of Biochemistry, School of Life Sciences & Biotechnology, Korea University, Korea |
16:00-16:20 |
Title: IL-6 Trans-signaling Regulation of Immune Responses and Inflammation in Rheumatoid Arthritis
Dr. Charles J. Malemud, Professor, Case Western Reserve University, USA |
16:20-16:40 |
Title: PI3 Kinase and Protein Kinase B (Akt) Play Central Roles in Regulating Intestinal Epithelial Cell Proliferation, Migration and Apoptosis: Implications in Intestinal Pathology
Dr. Tamas Jilling, Research Associate Professor, The Ellrodt-Schweighauser Family Chair of Perinatal Research, NorthShore University HealthSystem, Research Institute, Evanston Hospital, USA |
16:40-17:00 |
Title: Regulation of HIPK2-mediated Apoptosis by Poly-ubiquitination and SUMO-modification
Dr. Cheol Yong Choi, Associate Professor, Department of Biological Science, Sungkyunkwan University, Republic of Korea |
17:00-17:20 |
Title: Protocadherin Arcadlin Regulates Seizure-induced Synaptic Loss by Activating p38 MAP Kinase Signaling
Dr. Shin Yasuda, Department of Neuropharmacology, Tokyo Metropolitan Institute for Neuroscience, Japan |
|
Session 5-3: Protein Kinase Inhibitors in Cancer
Time: March 22, 2010 08:30-10:20 |
Session Chair |
Dr. Maurizio Salvadori, Professor, University of Florence, Italy |
08:30-08:50 |
Keynote Speaker
Title: From Screening to Clinic, Discovery of a Novel Allosteric MEK Inhibitor
Dr. Henry Yu, Senior Principal Investigator, Chemistry, EMD Serono Research Institute, Inc. , USA |
08:50-09:10 |
Title: Antineoplastic Effect of Proliferation Signal Inhibitors: from Biology to Clinical Application
Dr. Maurizio Salvadori, Professor, University of Florence, Italy |
09:10-09:30 |
Title: Exploring FGFR4 as a Potential Drug Target for the Treatment of Hepatocellular Carcinoma
Dr. Ho Han Kiat, Assistant Professor, Department of Pharmacy, National University of Singapore, Singapore |
09:30-09:50 |
Title: The MEK/ERK Signaling Pathway Affects Turnover of an ABC Transporter, ABCG2, Which Causes Multidrug Resistance of Cells
Dr. Yasuo Imai, Associate Professor, Department of Pathology, Dokkyo Medical University Koshigaya Hospital, Japan |
09:50-10:10 |
Title: Biological Impact of Freezing Plk1 (polo-like kinase 1) in Its Inactive Conformation by a Novel Potent Type II Kinase Inhibitor
Dr. Birgit Spankuch, Goethe-University, Medical School, Germany |
10:10-10:20 |
Coffee Break |
|
Session 5-4: Protein Kinase and Cell Cycle Control
Time: March 22, 2010 08:30-12:10 |
Session Chair |
Dr. Rainer Hedrich, Professor, University of Wuerzburg, Biocenter, Germany |
08:30-08:55 |
Title: Control of Mitosis by Unexpected Protein Kinases
Dr. Claude Prigent, Director, IGDR, Research Institute of Genetics and Development, CNRS, France |
08:55-09:20 |
Title: Activity of Guard Cell Anion Channel SLAC1 is Controlled by Drought-stress Signaling Kinase-phosphatase Pair
Dr. Rainer Hedrich, Professor, University of Wuerzburg, Biocenter, Germany |
09:20-09:45 |
Title: Protein Kinases in the Ion-transporting ATPases World: A Fascinating Talk about Energy Interconversion
Dr. Adalberto Vieyra, Professor of Biophysics and Physiology, Head, Laboratory of Biological Physical Chemistry, Institute of Biophysics Carlos Chagas Filho and National Institute of Structural Biology and Bioimage, Brazil |
09:45-10:10 |
Title: Role of PKC-iota in Cancer Cell Proliferation and Survival
Dr. Mildred Acevedo-Duncan, Research Associate Professor, Department of Chemistry, USF, VA Research, USA |
10:10-10:30 |
Coffee Break |
10:30-10:55 |
Title: The Roles of Cell Cycle Proteins and Protein Kinase Inhibitors in Normal and Pathological Placental Development
Dr. Emin Turkay Korgun, Associate Professor, Department of Histology and Embryology, Medical Faculty, Akdeniz University, Turkey |
10:55-11:20 |
Title: Protein Kinase Activation and Cardioprotection by Regular Ethanol Consumption and Volatile Anesthetics
Dr. Masami Miyamae, Department of Internal Medicine, Osaka Dental University, Japan |
11:20-12:10 |
Panel Discussion |
|
Session 5-5: Receptor Tyrosine Kinases
Time: March 22, 2010 13:30-17:30 |
Session Chair |
Dr. Nancy L. Lewis, Director, Phase I Clinical Trial Program, Cooper Cancer Institute, USA |
Co-Chair |
Dr. Xi-Long Zheng, Associate Professor, Senior Scholar of Alberta Heritage Foundation for Medical Research, Department of Biochemistry and Molecular Biology, Libin Cardiovascular Institute of Alberta, Smooth Muscle Research Group, The University of Calgary, Canada |
13:30-13:55 |
Title: The Insulin-Like Growth Factor Receptor as a Target for Novel Cancer Therapies
Dr. Nancy L. Lewis, Director, Phase I Clinical Trial Program, Cooper Cancer Institute, USA |
13:55-14:20 |
Title: Regulation of Cell Growth by Chloride Ion via MAPK-dependent Pathways
Dr. Yoshinori Marunaka, Professor and Chairman, Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Japan |
14:20-14:45 |
Title: Signaling Pathways Controlling Epithelial Integrity and Shape
Dr. Christian Dahmann, Group Leader, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany |
14:45-15:10 |
Title: Differential Roles of the Mitogen-Activated Protein Kinase Pathway in Smooth Muscle
Dr. Xi-Long Zheng, Associate Professor, Senior Scholar of Alberta Heritage Foundation for Medical Research, Department of Biochemistry and Molecular Biology, Libin Cardiovascular Institute of Alberta, Smooth Muscle Research Group, The University of Calgary, Canada |
15:10-15:30 |
Coffee Break |
15:30-15:55 |
Title: Function and Cell Surface Expression of insulin Receptor and IGF-I Receptor in Neuronal Cells
Dr. Toshihiko Yanagita, Assistant Professor, Department of Pharmacology, Miyazki Medical College, University of Miyazaki, Japan |
15:55-16:20 |
Title: When Phosphatases Support Kinases: Regulation of Bone Resorption in vivo by Protein Tyrosine Phosphatase Epsilon
Dr. Ari Elson, Associate Professor, Department of Molecular Genetics, The Weizmann Institute of Science, Israel |
16:20-16:45 |
Title: Role of Protein Kinases in the Regulation of Vascular Growth and Tumor Progression
Dr. Yulong He, Principal Investigator, Laboratory of Vascular and Cancer Biology, Model Animal Research Institute, Nanjing University, China |
16:45-17:10 |
Title: The Signaling Pathways and Biological Properties of Novel Oncogne with Kinase-domain (NOK)
Dr. Li Liu, Professor, Microbiology, Institute of Basic Medical, Sciences, CAMS & PUMC, China |
17:10-17:30 |
Panel Discussion |
|
Session 5-6: The EGF Receptor and Associated Signaling
Time: March 22, 2010 13:30-17:30 |
Session Chair: |
Dr. Anja Nohe, Assistant Professor, Department of Biological Sciences, Wolf Hall, University of Delaware, USA |
Co-Chair: |
Dr. Kenneth L. van Golen, Assistant Professor, Department of Biological Sciences, University of Delaware, USA |
| 13:30-13:50 |
Title: Role of Co-receptors and of the Actin Cytoskeleton to Receptor Tyrosine Kinase Signaling
Dr. Peter Herrlich, Professor of Molecular Biology Scientific Director, Leibniz Institute for Age Research - Fritz Lipmann Institute, Germany |
| 13:50-14:10 |
Title: The Epidermal Growth Factor (EGF) Receptor in Inflammatory Breast Cancer Metastasis
Dr. Kenneth L. van Golen, Assistant Professor, Department of Biological Sciences, University of Delaware, USA |
| 14:10-14:30 |
Title: Role of BMPs and EGF-like Growth Factors in Regulating Ovarian Function
Dr. Shunichi Shimasaki, Professor, Reproductive Medicine, University of California, San Diego, USA |
| 14:30-14:50 |
Title: Regulation of EGF Signaling by Bone Morphogenetic Protein 2
Dr. Anja Nohe, Assistant Professor, Department of Biological Sciences, Wolf Hall, University of Delaware, USA |
| 14:50-15:10 |
Title: Regulation of Actin Cytoskeleton via EGF Signaling
Dr. Laszlo Buday, Deputy Director, Institute of Enzymology, Biological Research Center, Hungary |
| 15:10-15:30 |
Coffee Break |
| 15:30-15:50 |
Title: Positive and Negative Modulators of EGF Receptor Signaling
Dr. Laura Moro, Associated Professor, Lab of Applied Biology, DISCAFF, University of Piemonte Orientale “A. Avogadro”, Italy |
| 15:50-16:10 |
Title: Nucleolin Interactions with ErbB Receptors: Effects on EGFR Activation and Anchorage Independent Growth
Dr. Pinkas-Kramarski Ronit, Associate Professor, Department of Neurobiology, Tel-Aviv University, Israel |
| 16:10-16:30 |
Title: Rotation/twist Model for the Molecular Mechanism underlying the Activation of the EGF/ErbB Receptor Family
Dr. Ichiro Maruyama, Senior Investigator, Okinawa Institute of Science and Technology, Japan |
| 16:30-16:50 |
Title: Modulation of Radiation Response via EGFR/HER-2 Associated Signaling
Dr. In Ah Kim, Associate Professor, Seoul National University, School of Medicine, South Korea |
| 16:50-17:10 |
Title: Two Phosphodegrons Targeting TAZ for SCFβ-TrCP Dependent Degradation in Response to Different Signals
Dr. Qunying Lei, Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Fudan University, Shanghai, China |
| 17:10-17:30 |
Title: MRL Proteins: Linking EGF Signalling to Tissue Growth, Invasive Cell Migration and Cancer Metastasis
Dr. Daimark Bennett, University of Liverpool, UK |
|
Session 5-7: Bacterial Protein Kinases
Time: March 23, 2010 08:30-10:40 |
Session Chair |
Dr. Gottfried Unden, Professor, Microbiology and Wine Research, Johannes Gutenberg University, Germany |
08:30-08:50 |
Title: Fine-tuning of a Histidine Kinase/Response Regulator System by Accessory Proteins in Escherichia Coli
Dr. Kirsten Jung, Professor, Ludwig-Maximilians-Universitaet Muenchen, Germany |
08:50-09:10
|
Title: Transmembrane Sensing His Kinase DcuS of Bacteria: Structural and Functional Aspects
Dr. Gottfried Unden, Professor, Johannes Gutenberg-Universitat Mainz, Institut für Mikrobiologie und Weinforschung, Germany |
09:10-09:30
|
Title: Threshold Level of a Sensor Histidine Kinase Governs Cell Fate in a Sporulating Bacterium
Dr. Masaya Fujita, Assistant Professor, Department of Biology and Biochemistry, University of Houston, USA |
09:30-09:50
|
Title: Molecular Basis for Light Regulation of Phototropin Kinase
Dr. Satoru Tokutomi, Professor, Department of Biological Science, Graduate School of Science, Osaka Prefecture University, Japan |
09:50-10:10 |
Title: Development of the Inhibitors Targeting WalK/WalR, Two-Component Signal Transduction System, Essential for Bacterial Cell Growth
Dr. Ryutaro Utsumi, Professor, Bioscience, Graduate School of Agriculture, Kinki University, Japan |
10:10-10:30 |
Title: Functional Analysis of Hisitidine Kinases in the Cyanobacterium Synechocystis sp. PCC 6803 Using Chimeric Sensor System
Dr. Iwane Suzuki, Associate Professor, Graduate School of Life and Environmental Sciences, University of Tsukuba; Program Officer, Grants-in Aid for Scientific Research (KAKENHI), Ministry of Education, Culture, Sports, Science and Technology, Japan |
10:30-10:40 |
Coffee Break |
|
Session 5-8: The AKT/PI 3-Kinases, and The MAP Kinase Pathway
Time: March 23, 2010 10:40-11:20 |
Session Chair |
Dr. Gottfried Unden, Professor, Microbiology and Wine Research, Johannes Gutenberg University, Germany |
10:40-11:00 |
Title: PTEN as a Suppressive Regulator in Folliculogenesis
Dr. Akira Iwase, Assistant Professor, Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Japan |
11:00-11:20 |
Title: The Role of Melanocortins in Adipocytes: from Fat to Facts
Dr. Alexandra Gouveia, Investigator, University of Porto, Portugal |
|
Session 5-9: Protein Kinases as Targets for Metabolic Disease
Time: March 23, 2010 11:30-12:20 |
Session Chair |
Dr. Gottfried Unden, Professor, Microbiology and Wine Research, Johannes Gutenberg University, Germany |
11:20-11:40 |
Keynote Speaker：
Title: Appetite Enhancement & Weight Gain by Peripheral TrkB Agonists in Non-human Primates
Dr. John C. Lin, Executive Director, Research, Pfizer Inc. USA
Presenter: Dr. David Tsao, Senior Scientist, Pfizer Inc. USA |
11:40-12:00 |
Title: AMPK as a Drug Target in Metabolic Diseases - Molecular Approach to Drug Design
Dr. Robert Jarzyna, Department of Metabolic Regulation, Institute of Biochemistry, Warsaw University, Poland |
12:00-12:20 |
Title: Diabetes and Key Steps Downstream AMP Kinase
Dr. F.R. van der Leij, Senior Lecturer in Molecular Biology, Life Sciences & Technology, Van Hall Larenstein & NHL University of Applied Sciences, The Netherlands |
|
Session 5-10: Wnt / Hedgehog / Notch Signaling Pathways
Time: March 23, 2010 13:30-15:00 |
Session Chair |
Dr. Roland Le Borgne, PI, Director of Resarch 2 (DR2) CNRS, Developmental Cell Biology, Université de Rennes, France |
13:30-13:55 |
Title: Epsins and Notch Signaling in Mammals
Dr. Ottavio Cremona, Professor of Human Anatomy Università Vita-Salute San Raffaele& IFOM - FIRC Institute of Molecular Oncology, Italy
Presenter: Dr. Alessandra Zattit |
13:55-14:20 |
Title: Drosophila Clathrin Adaptor AP-1 Complex Regulates Notch Dependent Binary Cell Fate Decisions
Dr. Roland Le Borgne, PI, Director of Resarch 2 (DR2) CNRS, Developmental Cell Biology, Université de Rennes, France |
14:20-14:45 |
Title: The H3K27me3-demethylase dUTX is a Suppressor of Notch-Induced Tumors in Drosophila
Dr. Andreas Bergmann, MD Anderson Cancer Center, Department of Biochemistry & Molecular Biology,USA |
14:45-15:00 |
Coffee Break |
|
|
Session 5-11: Kinase Screening, Profiling, Identification and Lead Optimization
Time: March 23, 2010 15:00-17:30 |
Session Chair |
Dr. Jiaan Yang, VP of Drug Discovery Technology, Sundia MediTech Company, Ltd., China |
15:00-15:25 |
Keynote Speaker:
Title: Genome Wide Analysis of Kinase Binding Site Signatures
Dr. Abdelazize Laoui, Director Drug Design, Sanofi-Aventis, USA |
15:25-15:50 |
Title: Bridging Cheminformatic and Bioinformatic Space via Kinase Profiling: A Data Mining Approach
Dr. Yi Han, Sr. Principal Scientist, Discovery Chemistry, Hoffmann-La Roche Inc. USA |
15:50-16:15 |
Title: Effective Screening Protein Database for Inhibitor and Kinase Binding Site with Quantitative Analysis
Dr. Jiaan Yang, VP of Drug Discovery Technology, Sundia MediTech Company, Ltd., China |
16:15-16:40 |
Title: Screening Kinase Inhibitors with Microarray-Based Optical Assay
Dr. Zhenxin Wang, Professor of Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China |
16:40-17:30 |
Panel Discussion |
|
Session 5-12: Small Molecule Kinase Inhibitor Discovery
Time: March 23, 2010 13:30-15:30 |
Session Chair: |
Dr. Tomohisa NAGAMATSU, Professor and Head,Department of Drug Discovery and Development Division of Pharmaceutical Science Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University, Japan |
Co-Chair: |
Dr. Peter P. Sayeski, Associate Professor, Department of Physiology and Functional Genomics, University of Florida College of Medicine, USA |
13:30-13:55 |
Title: A Jak2 Tyrosine Kinase Inhibitor, G6, Suppresses Jak2-V617F Mediated Human Pathological Cell Growth
Dr. Peter P. Sayeski, Associate Professor, Department of Physiology and Functional Genomics, University of Florida College of Medicine, USA |
13:55-14:20 |
Title: Characterization of Upstream and Downstream Regulators of the MAP3K, MEKK3
Dr. Rich Vaillancourt, Associate Professor, Department of Pharmacology & Toxicology, University of Arizona College of Pharmacy, USA |
14:20-14:45 |
Title: Identifying and Targeting Intrinsic Cytoprotective Pathways as a Novel Rationale for Small Molecule Inhibitors to Treat Cancers
Dr. Yun Dai, Assistant Professor, Virginia Commonwealth University/Massey Cancer Center, USA |
14:45-15:10 |
Title: Structure-activity Relationships and Docking Simulation into Protein Tyrosine Kinase for Flavins and Their Analogs as a New Class of Antitumor Agents
Dr. Tomohisa NAGAMATSU , Head of Molecular Pharmaceutical Chemistry Group, Department of Drug Discovery and Development, Division of Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Okayama University, Japan |
15:10-15:30 |
Coffee Break |
|
Session 5-13: Translation Regulation in the CNS
Time: March 23, 2010 15:30-17:30 |
Session Chair |
Dr. Kobi Rosenblum, Professor, Chair, Department of Neurobiology & Ethology, Center for Gene & Brain, Mount Carmel, Haifa University, Israel |
15:30-15:55 |
Keynote
Title: Translational Control of Synaptic Plasticity and Learning and Memory
Dr. Joel D. Richter, Professor, Program in Molecular Medicine, University of Massachusetts Medical School, USA |
15:55-16:20 |
Title: Enhancing Cognitive Function via Modulation of the Brain PKR Activity
Dr. Kobi Rosenblum, Professor, Department of Neurobiology, Center for Gene Manipulation in the Brain, University of Haifa, Haifa, Israel |
16:20-16:45 |
Title: Abnormal Development and Maintenance of Brain White Matter in Mice Carrying Hypomorphyc eIF2B5 Allels
Dr. Orna Elroy-Stein, Professor, Tel-Aviv University, Israel |
16:45-17:10 |
Title: Translation Initiation and Elongation Factors in Neurological Health and Disease
Dr. Christopher G. Proud, Professor of Cellular Regulation and Head, Biomolecular Sciences, Biological Sciences, University of Southampton, United Kingdom |
17:10-17:30 |
Panel Discussion |
|
Symposium 6: Protein Based Drug Discovery
Session 6-1: Target Discovery and Validations
Time: March 21, 2010 13:30-15:00 |
Session Chair: |
Dr. David H Solomon, President, Chief Executive Officer, ZEALAND Pharma A/S, Denmark |
Co-Chair: |
Dr. Xiayang Qiu, Director of Structural Biology, Biophysics and AB Computational Chemistry Pfizer Inc., USA |
13:30-13:50 |
Title: Molecular Insights into Protein and Protein-Ligand Interactions to Impact Drug Discovery
Dr. Xiayang Qiu, Director of Structural Biology, Biophysics and AB Computational Chemistry Pfizer Inc., USA |
13:50-14:10 |
Title: Peptide Based Drug Discovery – the Zealand Model
Dr. David H Solomon, President, Chief Executive Officer, ZEALAND Pharma A/S, Denmark |
14:10-14:30 |
Title: RXP-E: A Cx43-binding Peptide that Prevents Action Potential Propagation Block
Dr. Mario Delmar, Co-director, Center for Arrhythmia Research, Division of Cardiovascular Medicine, University of Michigan, USA |
14:30-14:50 |
Title: Discovery of Novel Small Peptidomimetics that Prevent Cardiac Gap Junction Closure and Action Potential Propagation Block. - From a 34 Amino Acid Peptide RXP-E to Active 3 Amino Acid Peptide Mimetics.
Dr. Bjarne Due Larsen, Intellectual Property & Innovation, Medicinal Chemistry, Zealand Pharma A/S, Denmark |
14:50-15:00 |
Coffee Break |
|
|
Session 6-2: GPCRs in Drug Discovery
Time: March 21, 2010 15:00-17:30 |
Session Chair: |
Dr. Annette Gilchrist, Assistant Professor, Pharmaceutical Sciences, Chicago College of Pharmacy, Midwestern University, USA |
Co-Chair: |
Dr. Betty Bei Yao, Senior Group Leader Neurological Disease Research, Global Pharmaceutical Discovery, Abbott Laboratories, USA |
15:00-15:20 |
Title: Pharmacological Chaperones: An Emerging Therapeutic Approach for Hereditary Diseases Caused by Mutations in G Protein-coupled Receptors
Dr. Ken Valenzano, Sr. Director, Pharmacology, Amicus Therapeutics, USA |
15:20-15:40 |
Title: Cannabinoid CB2 Receptor as a Target for Pain Modulation
Dr. Betty Bei Yao, Senior Group Leader Neurological Disease Research, Global Pharmaceutical Discovery, Abbott Laboratories, USA |
15:40-16:00 |
Title: Orphan Receptors Looking for a Function through Receptor Hetero-oligomerization?
Dr. Ralf Jockers, Research Director, INSERM, Institut Cochin, France |
16:00-16:20 |
Title: Identification of a Metabolically Stable Chemerin Analog as a Useful Pharmacological Tool
Dr. Shigeru Tokita, Research Group Manager, Molecular Biology, Taisho Pharmaceutical Co.,Ltd., Japan |
16:20-16:40 |
Title: Characterization of Subtype-selective Melatoninergic Ligands with Novel Non-indole Scaffolds
Dr. Maurice Kwok Chung HO, Senior Scientific Officer, Hong Kong University of Science and Technology, Hong Kong, China |
16:40-17:00 |
Title: Bioinformatics Approaches toward Controlling Protein-Protein Interaction between GPCRs
Dr. Wataru Nemoto, National Institute Advanced Industrial Science and Technology, Japan |
17:00-17:20 |
Title: Allosteric Modulators of GPCRs
Dr. Annette Gilchrist, Assistant Professor, Pharmaceutical Sciences, Chicago College of Pharmacy, Midwestern University, USA |
17:20-17:30 |
Panel Discussion |
|
Session 6-3: Protein Structure, Modeling, and Fragment-Based Drug Discovery
Time: March 22, 2010 08:30-10:00 |
Session Chair: |
Dr. Hong Wang, Senior Principal Scientist, Pfizer Global R&D, USA |
Co-Chair: |
Dr. Jun Xu, Professor of Medicinal Chemistry, Sun Yat-Sen University; CEO of KMS Meditech, Inc., China |
08:30-08:50 |
Keynote Speaker Invited
Title: Biophysics in Fragment Screening: Combination is Key
Dr. Matthias Frech, Research/ NCE Tech / LDT, Head of Molecular Interaction & Biophysics, Merck KGaA, Germany |
08:50-09:10 |
Title: Medicinal Chemistry Inspired by TCM Informatics
Dr. Jun Xu, Professor of Medicinal Chemistry, Sun Yat-Sen University; CEO of KMS Meditech, Inc., China |
09:10-09:30 |
Title: Applications of Protein NMR in Fragment Based Drug Discovery
Dr. Hong Wang, Senior Principal Scientist, Pfizer Global R&D, USA |
09:30-09:50 |
Title: Computational Study of a Potentially Bioactive Peptide for the Treatment and Diagnosis of Multiple Sclerosis
Dr. Carlo Guardiani, University of Florence, Italy |
09:50-10:00 |
Coffee Break |
|
Session 6-4: Transmembrane Peptides as Novel Therapeutics
Time: March 22, 2010 10:00-12:00 |
Session Chair: |
Dr. Dominique Bagnard, INSERM U682, University of Strasbourg, France |
Co-Chair: |
Dr Hang Yin, University of Colorado, Boulder, USA |
10:00-10:20 |
Title: Role of Interactions between Transmembrane Helices in Cell Signaling, More than Meets the Eye
Dr. Pierre Hubert, CNRS, France |
10:20-10:40 |
Title: Structural Aspects of transmembrane Helix Interactions: A Basis for Modulating Membrane Protein Folding, Stability and Function
Dr. Dirk Schneider, Professor, Johannes Guttenberg-University Mainz, Germany |
10:40-11:00 |
Title: Structural Requirements for APP Processing by g-secretase and Ab Oligomerization
Dr. Kienlen-Campard Pascal, Associate Professor, University of Louvain, Belgium |
11:00-11:20 |
Title: Transmembrane Peptide Targeting NRP1 as Efficient Anti-cancer Drug
Dr. Dominique Bagnard, Assistant Professor, University of Strasbourg, France |
11:20-11:40 |
Title: Self- assembly of Transmembrane Domains in CPT1: Role of GXXXG(A) Motif in Possible Channel Formation
Dr. Ann M. Dixon, Associate Professor, University of Warwick, UK |
11:40-12:00 |
Title: Rationally Designed Peptide Antagonists of the TLR4/MD2 Interaction
Dr. Hang Yin, Assistant Professor, University of Colorado at Boulder, USA |
|
Session 6-5: Protein Drug Delivery System and Nanotechnologies
Time: March 22, 2010 13:30-15:55 |
Session Chair: |
Dr. Lee Henderson, CEO and Founder, Vybion, Inc., USA |
13:30-13:55 |
Keynote
Title: Current Trend of Protein Drug Delivery Systems
Dr. Zeren Wang, Director, Pharmaceutics, Boehringer Ingelheim Pharmaceutics Inc, USA |
13:55-14:20 |
Title: A Simple Protein Transduction Technique with Unique Novel Features
Dr. Qianqian Li, Assistant Professor, Department of Biochemistry and Molecular Biology, School of Medicine, Wayne State University, USA |
14:20-14:45 |
Title: The Possible Use of Virus-like Particle of Human Papillomavirus as a Drug Delivery Carrier Based on the Increase of Cellular Uptake of a Small Molecule
Dr. Cheong-Weon Cho, Professor, Chungnam National University, Republic of Korea |
14:45-15:10 |
Title: Site-specific PEGylation to the His-Tag of an Antibody Fragment
Dr. Yuehua Cong, Research Project Manager, PolyTherics Ltd, UK |
15:10-15:30 |
Title: Exploring Modular Protein Engineering As a Novel Approach for Gene Therapy
Dr. Neus Ferrer-Miralles, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Spain |
15:30-15:55 |
Coffee Break |
|
Session 6-6: Design Drugs Targeting Protein-Protein Interactions
Time: March 22, 2010 15:55-17:30 |
Session Chair: |
Dr. Lee Henderson, CEO and Founder, Vybion, Inc., USA |
15:55-16:20 |
Keynote Speaker:
Title: ProCode: A Novel Platform to Optimize Antibody Affinity and Solubility with Broader Applications in Drug Development
Dr. Lee Henderson, CEO, Vybion, Inc., USA |
16:20-16:45 |
Title: Interaction of Anti-Microbial Peptides with Membranes –an NMR and Computational Study
Dr. Ulrich Sternberg, Professor, Karlsruhe Institute of Technology, Germany |
16:45-17:10 |
Title: Discovery and Development of Peptides Targetting Malaria Apical Membrane Antigen 1 (AMA1)
Dr. Andrew B. Hughes, Associate Professor,Department of Chemistry, La Trobe University, Australia |
17:10-17:30 |
Panel Discussion |
|
Session 6-7: New Peptides Drug Discovery
Time: March 23, 2010 08:30-12:10 |
Session Chair: |
Dr. Waleed Danho, Distinguished Research Leader, Hoffmann-LaRoche Inc., USA |
Co-Chair: |
Dr. Henry H. Sun, Chairman and President, Tasly America Inc.; Vice President, Tasly Group, Co., Ltd., China |
08:30-08:55 |
Keynote speaker:
Title: Therapeutic Peptides: Opportunities and Challenges
Dr. Waleed Danho, Distinguished Research Leader, Hoffmann-LaRoche Inc., USA |
08:55-09:20 |
Title: A New Pipeline for Drug Discovery: Bioven – a Process for Predictive High-throughput Peptide Drug Discovery.
Dr. Richard John Lipscombe, Director, Proteomics International, Australia |
09:20-09:45 |
Title: CIS Display: An in vitro Display Technology for the Selection of Therapeutic Proteins
Dr. Chris Ullman, CSO, Isogenica Ltd., UK |
09:45-10:10 |
Title: Structure Modification for Enhanced Bio-activity and Mass Production by Genetic Engineering of Therapeutic Peptides
Dr. Henry H. Sun, Chairman and President, Tasly America Inc.; Vice President, Tasly Group, Co., Ltd., China |
10:10-10:30 |
Coffee Break |
10:30-10:55 |
Title: Screening of Peptide Inhibitor Blocks Selectively the Interaction between Estrogen Receptors and Coactivators
Dr. Trang T. P. Phan, Chemical Genomics Centre (CGC), Max-Planck Institute of Molecular Physiology, Germany |
10:55-11:20 |
Title: Computer-Aided Design of Peptide Boronic Acid Proteasome Inhibitor
Dr. Yongqiang Zhu, Senior Scientist, Process Chemistry, Simcere Pharmaceutical Group, China |
11:20-11:45 |
Title: Corn Peptides as Alcohol Metabolism Stimulator and Hepatoprotective Agent
Dr. Hui He, Professor, Huazhong Agricultural University, China |
11:45-12:10 |
Panel Discussion |
|
Symposium 7: Protein Expression
Session 7-1: Advances in Control of Gene Expression and Alternative Expression
Time: March 21, 2010 13:30-15:30 |
Session Chair: |
Dr. Liling Tang, Director, Chongqing University, China |
13:30-13:50 |
Title: Post-Transcriptional Control of Chloroplast Gene Expression
Dr. Eva Maria Del Campo Lopez, Professor, Department of Plant Biology, University of Alcalá, Spain |
13:50-14:10 |
Title: Expression of IGF-I Alternative Splicing Variant Induced by Mechanical Signals and the Effects on the Physiological Behaviors of Osteoblasts
Dr. Liling Tang, Director, Chongqing University, China |
14:10-14:30 |
Title: Regulation of KNOX Gene Expression in Rice
Dr. Yukihiro Ito, Associate Professor, Tohoku University, Japan |
14:30-14:50 |
Title: Integrative Genomic Informatics of DNA Copy Number and Gene Expression Profiles Reveals Disease Pathways and Therapeutics Targets in Renal Cell Carcinoma
Dr. Kazuhiko Uchida, Associate Professor, University of Tsukuba, Japan |
14:50-15:10 |
Title: Gene Expression is a Circular Process
Dr. Mordechai Choder, Faculty of Medicine, Technion - Israel Institute of Technology, Israel |
15:10-15:30 |
Coffee Break |
|
Session 7-2: Eukaryotic/ Prokaryotic, Insect and Mammalian Expression
Time: March 21, 2010 15:30-17:30 |
Chair: |
Dr. George Lovrecz, Project Leader, CSIRO Molecular & Health Technologies, Australia |
15:30-15:50 |
Title: Glycoprotein Production in Single -use and Conventional Bioreactors
Dr. George Lovrecz, Project Leader, Molecular & Health Technologies, CSIRO, Australia |
15:50-16:10 |
Title: Efficient Production of Disulfide Bonded Proteins in the Cytoplasm of E.coli
Dr. Lloyd Ruddock, Professor of Protein Science, University of Oulu, Finland |
16:10-16:30 |
Title: Antibiotic-free Selection in E. coli: New Considerations for Optimal Design and Improved Production
Dr. Regis Sodoyer, Research Department, Sanofi Pasteur, France |
16:30-16:50 |
Title: High Quality Protein Production in the Insect Cell-Baculovirus System
Dr. Mónica Martínez Alonso, Institut de Biotecnologia i de Biomedicina, Autonomous University of Barcelona, CIBER-BBN, Spain |
16:50-17:10 |
Title: A Robust System for Production of Recombinant Proteins in Bacillus Subtilis
Dr. Hoang Duc Nguyen, Chemical Genomics Centre (CGC), Max-Planck Institute of Molecular Physiology, Germany |
17:10-17:30 |
Title: An Integrated Systems Approach for Recombinant Microbial Bioprocess Development
Dr. Monika Cserjan, Senior Scientist, University of Applied Life Sciences and Natural Resources, Austria
|
|
Session 7-3: Novel Protein Expression Systems and Sample Purification, Detection Technologies
Time: March 22, 2010 10:20-12:00 |
Session Chair: |
Dr. Jianjun Wang, Associate Professor, Wayne State University, USA |
10:20-10:40 |
Keynote Speech:
Title: Baculovirus as a Versatile Tool for Protein Expression in Insect and Mammalian Cells
Dr. Yu-Chan Chao, NSC Distinguished Research Fellow, Academia Sinica, Taiwan |
10:40-11:00 |
Title: Engineered Micro-Algae to Produce Therapeutic Proteins
Dr. Aude Carlier, CSO& Co-founder, Algenics, France |
11:00-11:20 |
Title: A Gram Quantity Bacterial Expression Method Without a Fermentor
Dr. Jianjun Wang, Associate Professor, Wayne State University, USA |
11:20-11:40 |
Title: Recombinant Spider Silk - New Life in an Old Horse?
Dr. Wilhelm Engstrom, Professor, Swedish University of Agricultural Sciences, Sweden |
11:40-12:00 |
Title: Plasmid-free T7-based Escherichia Coli Expression Systems-a Robust and Efficient Alternative for Recombinant Protein Production
Dr. Gerald Striedner, Senior Scientist, University of Applied Life Sciences and Natural Resources, Austria |
|
Symposium 8: Protein Biomarkers
Session 8-1: Protein Biomarker Discovery and Validation for Diagnosis and Treatment
Time: March 23, 2010 08:30- 10:35 |
Session Chair |
Dr. Herbert Thiele, Director Bioinformatics, Bruker Daltonik GmbH, Germany |
Co-Chair |
Dr. Manfred Raida, Group Leader, Experimental Therapeutics Centre, Singapore |
08:30-08:50 |
Title: Bioinformatics Strategies for Diagnosis and Biomarker Discovery in MALDI-TOF-MS? Profiles and MALDI TOF Images
Dr. Herbert Thiele, Director Bioinformatics, Bruker daltonik GmbH, Germany |
08:50-09:10 |
Title: Gb3, Lso-Gb3 and Metabolomic Studies Using Mass Spectrometry: How to Improve Monitoring of Fabry Disease Patients
Dr. Christiane Auray-Blais, Director, Provincial Mass Urine Screening Program; Scientific Director, Waters-CHUS Expertise Centre in Clinical Mass Spectrometry, Department of Pediatrics, CHUS-Faculty of Medicine and Health Sciences, Université de Sherbrooke, Canada |
09:10-09:30 |
Title: The Preeclampsia Biomarkers: Current Knowledge, Clinical Implications and Future Application.
Dr. Olav Lapaire, Deputy of the Maternal-Fetal Unit, Department of Obstetrics and Gynecology, University of Basel, Switzerland |
09:30-09:50 |
Title: Serological Identification of Alpha-Enolase as a Tumor-Associated Autoantigen and its Potential Medical Applications
Dr. Neng-Yao Shih, Assistant Investigator, National Institute of Cancer Research, National Health Research Institutes, Taiwan |
09:50-10:10 |
Title: Saliva Biochemical Markers for the Identification of Patients with Oral Cancer
Dr. Satoru Shintani, Director, Department of Oral & Maxillofacial Surgery, Showa Univ. School of Dentistry, Japan |
10:10-10:30 |
Title: ODAM – A Novel Biomarker for Epithelial Carcinomas
Dr. Charles Todd Bruker, Department of Pathology, University of Tennessee Medical Center Knoxville, USA |
10:30-10:35 |
Coffee Break |
|
Session 8-2: Toxicity Biomarkers and Biomarkers Assay Development
Time: March 23, 2010 10:35-12:15 |
Session Chair |
Dr. Paul Debbage, Professor, Department of Anatomy, Histology and Embryology, Medical University Innsbruck, Austria |
Co-Chair |
Dr. B. Sharma, Professor of Biochemistry &Chairman, Department of Biochemistry, Coordinator, Centre for Biotechnology, University of Allahabad, India |
10:35-10:55 |
Title: Multiplex Assays for Biomarker Research and Clinical Application Translational Science Coming of Age
Dr. Qin Fu, Director, Biomarker Validation, Johns Hopkins Bayview Proteomic Center, USA |
10:55-11:15 |
Title: Possible Biomarkers for Methionine Excess Determination
Dr. Ryosei Sakai, Chief Biochemist, Institute of Life Sciences, Ajinomoto Co., Inc., Japan |
11:15-11:35 |
Title: A New Biomarker of Protein Oxidation Degree and Site Using Angiotensin as the Target by MS
Dr. Rutao Liu, Professor, Deputy Dean, School of Environmental Sceince & Engineering, Shandong University, China |
11:35-11:55 |
Title: Identification of Enzymatic Source of Alanine Aminotransferase Activity in Serum from Dogs with Liver Injury
Dr. Masafumi Miyazaki, Infectious Diseases, Exploratory Research Laboratories, Kyorin Pharmaceutical Co., Ltd., Japan |
11:55-12:15 |
Title: Biomarkers and Their Applications
Dr. B. Sharma, Professor of Biochemistry &Chairman, Department of Biochemistry, Coordinator, Centre for Biotechnology, University of Allahabad, India |
|
Session 8-3: Protein Biomarkers for Cancers
Time: March 23, 2010 13:30-15:20 |
Session Chair |
Dr. Linsen Yang, Academic Marketing Manager, Marketing, Life Technologies, China |
Co-Chair |
Dr. Shan Lu, Assistant Professor, University of Cincinnati College of Medicine, USA |
13:30-13:50 |
Title: Discovery of Urinary Biomarkers in Urinary Tract Carcinoma and Kidney Disease
Dr. Vladisav Stefanovic, Professor, Internal Medicine, Nephrology, Clinical Research, University of Nis, Serbia |
13:50-14:10 |
Title: An In Vitro Model to Study Chemoresistance in Non-Hodgkins Lymphoma Patients Over-expressing Mutant p53
Dr. Diana Anderson, Professor, Established Chair in Biomedical Sciences, Division of Biomedical Sciences, School of Life Sciences, University of Bradford, UK |
14:10-14:30 |
Title: Rb Expression - A Biomarker in Urinary Bladder Carcinoma
Dr. Hans Olsson, Associate Professor, Pathology laboratory University hospital Linkoping, Sweden |
14:30-14:50 |
Title: Hakai, An E-Cadherin Binding Protein, As a Novel Tissue Based Tumour Progression Marker
Dr. Angélica Figueroa, Principal Investigator, Biomedical Research Institute (INIBIC), Medical Oncology Unit, A Coruka University Hospital, Spain |
14:50-15:10 |
Title: Biomarkers in the Development of Novel Formulations in Nanomedicine
Dr. Paul Debbage, Professor, Department of Anatomy, Histology and Embryology, Medical University Innsbruck, Austria |
15:10-15:20 |
Coffee Break |
|
Session 8-4: Protein Biomarkers for Diseases: Cardiovascular, CNS, Inflammation and Immunology
Time: March 23, 2010 15:20-17:00 |
Session Chair |
Dr. Linsen Yang, Academic Marketing Manager, Marketing, Life Technologies, China |
Co-Chair |
Dr. Shan Lu, Assistant Professor, University of Cincinnati College of Medicine, USA |
15:20-15:40 |
Title: Proteomic studies of Patients with Ocular Surface Inflammation Implicates the S100 A8/A9 proteins
Dr. Roger Beuerman, Senior Scientific Director, Singapore Eye Research Institute (SERI), Singapore National Eye Center, Singapore |
15:40-16:00 |
Title: Neuroproteomic Dementia Biomarkers: Status Quo and Perspectives
Dr. Jens. Wiltfang, Professor, University of Duisburg-Essen, Germany |
16:00-16:20 |
Title: Alteration of Histone Acetylation in the Retinas of Diabetes: A 2D-DIGE Study
Dr. Ling Zheng, Professor of Pathology, College of Life Sciences, Wuhan University, China |
16:20-16:40 |
Title: Biomarker Discovery: Advancing Discovery with ProtoArray Technology
Dr. Linsen Yang, Academic Marketing Manager, Marketing, Life Technologies, China |
16:40-17:00 |
Title: Gla Rich Protein (GRP), A New Biomarker For Ectopic Calcifications?
Dr. Dina Costa Simes, GenoGla Diagnostics and University of Algarve/CCMAR, Portugal |
|
Session 8-5: Biomarker for Personalized Medicine
Time: March 23, 2010 17:00-17:40 |
Session Chair |
Dr. Agneta Siegbahn, Professor in Clinical Coagulation Science, Uppsala University, Department of Medical Sciences, Uppsala University, Sweden |
Co-Chair |
Dr. Shan Lu, Assistant Professor, University of Cincinnati College of Medicine, USA |
17:00-17:20 |
Title: An Integrative Genomic and Proteomic Approach to Chemosensitivity Prediction
Dr. Lan Guo, Assistant Professor of Community Medicine, Co-Director of WVU CTSI for Biomedical Informatics, Adjunct Assistant Professor of Computer Science, West Virginia University, USA |
17:20-17:40 |
Title: Vav3 Oncogene Signaling in the EGFR/HER2-elicited Multiple Pathways in Development, Progression, and Theragnosis of Prostate Cancer
Dr. Shan Lu, Assistant Professor, University of Cincinnati College of Medicine, USA |
|
Symposium 9: Protein as Biocatalysts and Biomaterials
Session 9-1: Protein Design and Evolution for Enzymes
Time: March 21, 2010 13:30-15:30 |
Session Chair |
Dr. Bouzid Menaa, Research Program Director, Nanotechnology Division, Fluorotronics, Inc., USA |
13:30-13:50 |
Title: Molecular Evolution in Quaternary Structure of an Essential Bacterial Enzyme
Dr. Matthew Perugini, Senior Lecturer, Department of Biochemistry and Molecular Biology, University of Melbourne, Australia |
13:50-14:10 |
Title: A Third Generation of Uronium and Phosphonium Type-Based Coupling Reagent
Dr. Ayman El-Faham, Professor, King Saud University, Kingdom of Saudi Arabia |
14:10-14:30 |
Title: Pig Liver Esterase - Re-introducing a Valuable Biocatalyst into Industrial Processes
Dr. Harald Pichler, Assistant Professor, Graz University of Technology & Research Centre Applied Biocatalysis, Austria |
14:30-14:50 |
Title: Genetically Enhanced Enzymes as Antibacterial Therapies
Dr. Karl E. Griswold, Assistant Professor, Dartmouth College, USA |
14:50-15:10 |
Title: Engineering Enzymes for Prodrug Activation Therapy
Dr. Kristian M. Müller, Group Leader, Department of Biology, University of Freiburg, Germany |
15:10-15:30 |
Coffee Break |
|
Session 9-2: Protein Biomaterial Design and Implications
Time: March 21, 2010 15:30-17:30 |
Chair |
Dr. Bouzid Menaa, Research Program Director, Nanotechnology Division, Fluorotronics, Inc., USA |
15:30-15:50 |
Title: Proteins in Nanoporous Silica-based Sol-gel Glasses: from Bioencapsulation and Surface Adsorption to Protein Folding Studies
Dr. Bouzid Menaa, Research Program Director, Nanotechnology Division, Fluorotronics, Inc., USA |
15:50-16:10 |
Title: Polymer-Protein Hybrid Materials for Tissue Replacement
Dr. Luiz Henrique Catalani, Professor & Leader, Laboratory of Polymeric Biomaterials, Institute of Chemistry, University of Sao Paulo, Brazil |
16:10-16:30 |
Title: Corn Protein: a New Kind of Biomaterials as Bone Substitute
Dr. Jinye Wang, Professor, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, China |
16:30-16:50 |
Title: Bacterial Inclusion Bodies: a New Functional and Biocompatible Nanomaterial
Dr. Elena García-Fruitós, CIBER-BBN Bioingeniería, Biomateriales y Nanomedicina, Institute for Biotechnology and Biomedicine, Applied Microbiology, Autonomous University of Barcelona, Spain |
16:50-17:10 |
Title: Molecular Functions Designed in Protein Nanocage Assemblies
Dr. Takafumi Ueno, Associate Professor, Institute for Integrated Cell-Material Sciences, Kyoto University, Japan |
17:10-17:30 |
Panel Discussion |
|
|
Symposium 10: Protein Analysis and Quality Control
Session 10-1: Progress of Analytical Techniques for Protein
Time: March 22, 2010 13:30-15:30 |
Chair |
Dr. Xueying Huang, President, Sepax Technologies, Inc., USA |
Co-Chair |
Dr. Rutao Liu, Professor, Deputy Dean, School of Environmental Sceince & Engineering, Shandong University, China |
13:30-13:55 |
Title: New Packing Materials for High Resolution of Monoclonal Antibodies
Dr. Xueying Huang, President, Sepax Technologies, Inc., USA |
13:55-14:20 |
Title: High Sensitivity LabChip? Applications for Quality Control and Characterization of Monoclonal Antibodies and Other Proteins
Dr. Raj Singh, Director of Assay Development, R&D Department, Caliper Life Sciences, USA |
14:20-14:45 |
Title: Analytical and Comparability Strategies for the Development and Evaluation of Follow-on Biologics
Dr. George Wang, Senior Director, Genor Biopharma, Co. Ltd., China |
14:45-15:10 |
Title: Proteomic Analysis of Membrane Proteins Expressed Specifically in Pluripotent Murine Embryonic Stem Cells
Dr. Akira Kurisaki, Senior Researcher, National Institute of Advanced Industrial Science and Technology, Japan |
15:10-15:30 |
Coffee Break |
|
Session 10-2: Chip and Array Technology for Protein Analysis
Time: March 22, 2010 15:30-17:30 |
Chair |
Dr. Xueying Huang, President, Sepax Technologies, Inc., USA |
Co-Chair |
Dr. Rutao Liu, Professor, Deputy Dean, School of Environmental Sceince & Engineering, Shandong University, China |
15:30-15:55 |
Title: Traceless and Site-Specific Immobilization of Proteins onto Solid Supports using Proteinf Trans-splicing
Dr. Julio A. Camarero, Associate Professor, Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, USA |
15:55-16:20 |
Title: Microcantilever Based Protein Quantification with Different Linkers and Receptors
Dr. Sang Kyung Kim, Korea Institute of Science and Technology, Korea |
16:20-16:45 |
Title: Microchip Capillary Electrophoresis Electrospray Ionization Mass Spectrometry for Rapid Characterization of Recombinant Human Erythropoietin
Dr. Tiina Marjukka Sikanen, University of Helsinki, Finland |
16:45-17:10 |
Title: Proteomic Analysis of Aminoglycoside Resistance in Mycobacteria
Dr. Deepa Bisht, Scientist-C, Deptt. of Biochemistry, NJIL&OMD (ICMR), India |
17:10 -17:30 |
Panel Discussion |
|
Session 10-3: HPLC, LC-MS and SFC in Protein Analysis
Time: March 23, 2010 08:30-10:30 |
Session Chair |
Dr. Liyu Yang, Associate Director, Bioanalytical Sciences, Drug Metabolism and Pharmacokinetics, Biogen Idec, Inc, USA |
Co-Chair |
Dr. Patrick J. Rudewicz, Director, Metabolism and Bioanalytical, Drug Metabolism and Pharmacokinetics, Elan Pharmaceuticals, Inc, USA |
08:30-08:50 |
Keynote Speaker:
Title: Characterization of Monoclonal Antibodies and Components Using Ultra-Performance Liquid Chromatography (UPLC) Technology
Dr. Dorothy J. Phillips, Director, Waters Corporation, USA |
08:50-09:10 |
Title: Quantitative and Qualitative LC/MS Methods for Peptides and Antibody-Drug Conjugates
Dr. Liyu Yang, Associate Director, Bioanalytical Sciences, Drug Metabolism and Pharmacokinetics, Biogen Idec, Inc, USA |
09:10-09:30 |
Title: The Study of Peptide Drug Metabolism Using Mass Spectrometry
Dr. Patrick J. Rudewicz, Director, Metabolism and Bioanalytical, Drug Metabolism and Pharmacokinetics, Elan Pharmaceuticals, Inc, USA |
09:30-09:50 |
Title: Technology to Enhance Quantitative Analysis in Complex Samples
Dr. Xu Guo, Application Scientist, Product Application Laboratory, AB SCIEX, Canada |
09: 50-10:10 |
Title: Advanced Cellulose Base Strong Ion Exchange Chromatography Media
Dr. Masami Todokoro, Manager, Fine Chemicals Department, Chisso Corporation, Japan |
10:10-10:30 |
Coffee Break |
|
Session 10-4: Spectroscopic Analysis and other GMP Compliance Analytical Methods
Time: March 23, 2010 10:30-12:10 |
Chair |
Dr. Liyu Yang, Associate Director, Bioanalytical Sciences, Drug Metabolism and Pharmacokinetics, Biogen Idec, Inc, USA |
Co-Chair |
Dr. Patrick J. Rudewicz, Director, Metabolism and Bioanalytical, Drug Metabolism and Pharmacokinetics, Elan Pharmaceuticals, Inc, USA |
10:30-10:50 |
Title: Elucidation of Protein Oxidation by ESR, NMR and FT-Raman Spectroscopy
Dr. Nazlin Howell, Professor, University of Surrey, UK |
10:50-11:10 |
Title: Quantifying Protein Aggregation
Dr. Hui Ning, Product Specialist, Nanometrics, Malvern Instruments China, China |
11:10-11:30 |
Title: Vibrational Spectroscopy for Molecular Characterization of Proteins in the Diseased Skin of Dermatological Patients
Dr. Natalja Skrebova Eikje, Director, MC Professional Oü, Estonia |
11:30-11:50 |
Title: Spectroscopic Studies of Changes in Plasma Lipoproteins Induced by External Factors
Dr. Dubravka Krilov, Associate Professor of Physics, University of Zagreb, Croatia |
11:50-12:10 |
Title: High Sensitivity Aggregate Detection in Antibody Formulations
Dr. Kevin Mattison, Senior Bioanalytical Scientist, Malvern Instruments Inc., USA |
|
Symposium 11: Protein Process Development and Manufacturing
Session 11-1:
Cell Line Engineering and Development
Time: March 21, 2010 13:30-17:30 |
Session Chair: |
Dr. Jianguo Yang, Principal Scientist and Group Leader, Genzyme, USA |
Co-Chair: |
Dr Thomas Jostock, Principal Scientist, Novartis, Switzerland |
13:30-13:50 |
Keynote Speaker:
Title: Challenges in Production Cell Line Development
Dr. Jianguo Yang, Principal Scientist and Group Leader, Genzyme, USA |
13:50-14:10 |
Title: Efficient Screening for Highest Producing Mammalian Cell Clones
Dr. Christopher J. Mann, Senior Application Support Specialist, Genetix Inc., UK |
14:10-14:30 |
Title: Next Generation of CHO-DHFR Selection System to Rapidly Create High-producing Stable Cell Line without MTX Amplification
Dr. Xiaoyun Wu, CEO, ADV Bioscience LLC, USA |
14:30-14:50 |
Title: High-throughput Expression Platform for Recombinant Human Antibody Cell Line Generation
Dr. Cheng Liu, CEO & President, Eureka Therapeutics Inc., USA |
14:50-15:10 |
Title: Accelerating CHO Cell Line Development by Implementing New Technologies
Dr. Thomas Jostock, Principal Scientist, Novartis, Switzerland |
15:10-15:30 |
Coffee Break |
15:30-15:50 |
Title:Transient Expression as a Diagnostic Tool for Identification of Potentially Problematic Attributes before Stable Cell Line Development
Dr. Janet Cheng, Principal Scientist, Amgen, USA |
15:50-16:10 |
Title: Creation of High-Producer Host Cell Lines for Antibody Production Using Disparity Mutagenesis Technology
Dr. Kaori Mine, Director of Global Business Development, Neo-Morgan Laboratory Inc., Japan |
16:10-16:30 |
Title: Designing Automated Systems for Accelerating Cell Line Development.
Dr. Robert Lund, Group Manager, Beckman Coulter Inc, USA |
16:30-16:50 |
Title: Scaffold-free Cartilage Tissue Model Cultured Under Mechanical Stress Loading
Dr. Katsuko S Furukawa, Associate Professor, University of Tokyo, Japan |
16:50-17:10 |
Title：The Industrialisation of Soybean Bioactive Peptides Microbial Fermentation Program
Mr. Mingxue Sun, the Vice Chairman and the Director, Xi’an Guocui Peptide Biology Co. Ltd., China |
17:10-17:30 |
Panel Discussion |
|
Session 11-2: Improved Separation, Purification, Recovery, Crystallization, and Lyophilization
Time: March 22, 2010 08:30-10:55 |
Session Chair: |
Dr. Henry C Chiou, Principal Scientist, Life Technologies, USA |
08:30-08:50 |
Keynote Speaker:
Title: Downstream Processing 2.0: From a Bottleneck to a Pacemaker
Dr. Yujing Yang, Director, Purification Technologies North America, USA |
08:50-09:10 |
Title: Introduction and Application of Bioseparation Media, TOYOPEARL for Separation of Monoclonal Antibody
Dr. Oscar Yamasaki, General Manager, Sales & Marketing Dept. Tosoh co., Inc., Japan |
09:10-09:30 |
Title: Efficient and Flexible Process for Recombinant Therapeutic Protein Production
Dr. Michelle Xia, Vice President, Crown Bioscience Inc., USA |
09:30-09:50 |
Title: A New Strategy for Purification of Intact Proteins Simultaneously Satisfying with High Resolution, High Speed, High Sample Loading
Dr. Xindu Geng, Full Professor, Director of Institute of Modern Separation Science, Northwest University, China |
09:50-10:10 |
Title: A Multi-Mode Interaction Theory for Predicting Protein Elution Profiles in Isoelectric Chromatofocusing
Dr. Derek Yau Chung Choy, Michael Smith Laboratories, Canada |
10:10-10:30 |
Title: A Novel Recombinant System for Efficient Expression of Unstable Proteins--Using a New Fusion Affinity Tag and High-performance Cleavage Enzyme
Dr. Tomohisa Ogawa, Associate Professor, Tohoku University, Japan |
10:30-10:50 |
Title: Arginine as a Versatile Reagent for Handling Proteins
Dr. Kouhei Tsumoto, Associate Professor, The University of Tokyo, Japan |
10:50-10:55 |
Coffee Break |
|
Session 11-3: Scaling Up Bioprocess Development for Biotherapeutics
Time: March 22, 2010 10:55-12:15 |
Session Chair: |
Dr. Henry C Chiou, Principal Scientist, Life Technologies, USA |
Co-Chair: |
Dr. Xiaojian(David) Zhao, Director, Research and Development, EMD Chemicals Inc., USA |
10:55-11:15 |
Title: Novel Approach to Chemically Defined Platform Medium and Feed Development for CHO Cell Culture
Dr. Xiaojian(David) Zhao, Director, Research and Development, EMD Chemicals Inc., USA |
11:15-11:35 |
Title: Key Considerations in Upscaling Transient Bioproduction in HEK293 and CHO Cells and Alignment with Stable Cell Line Development
Dr. Henry C Chiou, Principal Scientist, Life Technologies, USA |
11:35-11:55 |
Title: PURE System for Production of Target Protein and Antibody Drugs
Dr. Takuya Ueda, Professor, The University of Tokyo, Japan |
11:55-12:15 |
Title: Optimization and Validation of Virus Filtration Process
Dr. In Seop Kim, Associate Professor, Department of Biological Sciences, Hannam University, South Korea |
|
Session 11-4:
Cell Culture and Up- Stream Process Development
Time: March 22, 2010 13:30-15:30 |
Session Chair: |
Dr. Xiao Ping Dai, Assistant Director, Medarex Inc., USA |
13:30-13:50 |
Title: On-Line Monitoring: Animal Cell Cultivation in Suspension and Fixed-Bed Bioreactor Using Dielectric Measurements and Spectroscopy Scanning
Dr. Olivier Berteau, Director, Fogale Nanotech, France |
13:50-14:10 |
Title: Platform Strategy for Upstream Process Development - Streamlining Efficiency, Product Quality, Technology Transfer and Scale Up
Dr. Xiao Ping Dai, Assistant Director, Medarex Inc., USA |
14:10-14:30 |
Title: Development and Implementation of Harmonized Cell Culture Process for Therapeutic Monoclonal Antibodies
Dr. Jun Luo, Sr. Engineer, Genetech Inc., USA |
14:30-14:50 |
Title: Contracting for Biopharmaceutical Process Development
Dr. William G. Whitford, Sr. Manager, BioProcessing Market, Thermo Fisher Scientific, USA |
14:50-15:10 |
Title: Human Blood Dendritic Cell Preparation, Culture, and Immunological Assay
Dr. Jong-Young Kwak, Professor/Director, Dong-A University, South Korea |
15:10-15:30 |
Coffee Break |
|
Session 11-5: New Protein Therapeutic Formulation Development
Time: March 22, 2010 15:30-17:30 |
Session Chair: |
Dr. Xiao Ping Dai, Assistant Director, Medarex Inc., USA |
15:30-15:50 |
Keynote Speaker
Title: Studies of Protein Aggregation and Particulates in Support of GMP Manufacturing
Dr. Li Shi, Senior Director, Genzyme, USA
Presenter: Dr. Yang Jianguo |
15:50-16:10 |
Title: Functional Proteins and Peptides in Human Milk and Pediatric Nutrition
Dr. Eduard K. Poels, Vice President, Mead Johnson Nutrition, USA |
16:10-16:30 |
Title: Sustained Delivery of Proteins and Peptides: Experience with Mutivesicular Liposomes
Dr. William J. Lambert, Senior Vice President, Pharmaceutical Development, Pacira Pharmaceuticals, Inc.,USA |
16:30-16:50 |
Title: Monitoring and Predicting Protein Formulation Stability Using Non-Invasive Light Scattering Techniques
Dr. Kevin Mattison, Senior Bioanalytical Scientist, Malvern Instruments Inc., USA |
16:50-17:10 |
Title: Furin as an Established Endoproteolytic Proprotein Processing Tool for Enhanced Manufacturing of Recombinant Biopharmaceutical Proteins.
Dr. Willem Van de Ven, Professor, University of Leuven, Belgium |
17:10-17:30 |
Panel Discussion |
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Symposium 12: Proteins as Drugs-Non-Antibody and Non-Vaccine Protein Therapeutics
Session 12- 1: Proteins as Drugs-Non-Antibody and Non-Vaccine Protein Therapeutics
Time: March 23, 2010 08:30-12:10 |
Session Chair |
Dr. Nathalie Grandvaux, Canada Research Chair in Signaling and Virus Infections, Dept of Biochemistry and CHUM Research Center , University of Montreal, Canada |
Co-Chair |
Dr. Wei-Chiang Shen, Professor in Pharmaceutical Sciences, University of Southern California, USA |
08:30-08:50 |
Keynote Speaker:
Title: Recombinant Granulocyte Colony-Stimulating Factor and Transferrin Fusion Proteins as Myelopoietic Agents
Dr. Wei-Chiang Shen, Professor in Pharmaceutical Sciences, University of Southern California, USA |
08:50-09:10 |
Title: Designing Automated Sample Preparation Systems for Flow Cytometry Analysis
Dr. Robert Lund, Group Manager, Beckman Coulter, USA |
09:10-09:30 |
Title: New Insight into the Redox Regulation of Proinflammatory and Antiviral Cytokines Production in RNA Virus Infections
Dr. Nathalie Grandvaux, Canada Research Chair in signaling and virus infections, Dept. of Biochemistry and CHUM Research center, University of Montreal, Canada |
09:30-09:50 |
Title: Molecular Mechanism of Growth Hormone Regulation of Insulin-like Growth Factor 1 Gene Expression
Dr. Honglin Jiang, Associate Professor, Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, USA |
09:50-10:10 |
Title: Molecular Mechanisms of Insulin and IGF Receptor Binding
Dr. Briony Forbes, Senior Research Fellow, Molecular and Biomedical Sciences, The University of Adelaide, AUSTRALIA |
10:10-10:30 |
Coffee Break |
10:30-10:50 |
Title: The Role of ZNF521 Protein in Hematopoietic Cells
Dr. Ikuya Sakai, Professor, College of Pharmaceutical Sciences, School of Clinical Pharmacy, Matsuyama University, Japan |
10:50-11:10 |
Title: How Do We Increase Insulin-like Growth Factor-I Production? ; the Molecular Mechanism and Possible Therapeutic Usefulness
Dr. Kenji Okajima, Professor, Department of Translational Medical Science Research, Nagoya City University, Japan |
11:10-11:30 |
Title: The Effects of Granulocyte Colony-Stimulating Factor (G-CSF) on Cardiac Mitochondria
Dr. Eri Iwai-Kanai, Associate Professor, Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Japan |
11:30-12:10 |
Panel Discussion |
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Workshop : Biotechnology and Technology Transfer
Time: March 23, 2010 13:30-14:15 |
Session Chair |
Mr. John P. Iwanicki, Esq., Principal Shareholder, Banner & Witcoff, Ltd., USA |
13:30-14:15 |
Title: Patents: The Sword and the Shield in a Highly Competitive Market
Mr. John P. Iwanicki, Esq., Principal Shareholder, Banner & Witcoff, Ltd., USA |
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Young Scientists Forum
Time: March 23, 2010 14:20-17:30
Place: 311C, 3F,BICC |
Session Chair |
Hsin-hao Timothy Hsiao, PhD candidate in Molecular Biophysics & Biochemistry, Yale University, USA |
14:20-14:45 |
Title: Reproducibility Assessement and Statistical Quantification in Mass Spec Data from Clinical Proteomics Study
Irene Zeng, PhD Student ,Faculty of Science, The University of Auckland, Newzealand |
14:45-15:10 |
Title: Tumor Repressive Function of Estrogen Receptor in Malignant Pleural Mesothelioma
Giulia Pinton, PhD Student, (DiSCAFF), University of Piemonte Orientale “Amedeo Avogadro”, Italy |
15:10-15:30 |
Coffee Break |
15:30-15:55 |
Title: At the Interface: Comparative Analysis Reveals the Structural Basis for FIR/PUF60 to Navigate between Transcriptional Regulation and pre-mRNA Splicing
Hsin-hao Timothy Hsiao, PhD candidate in Molecular Biophysics & Biochemistry, Yale University, USA |
15:55-16:20 |
Title: Primitive Metalloenzymes Inspired by Nature
Dr. Marc Creus, Postdoctoral Scientific Collaborator and HABILITAND (Group Leader), Department of Chemistry, University of Basel, Switzerland |
16:20-16:45 |
Title: Cell-penetrating Peptides (CPPs) Facilitate the Uptake of Bioactive Cargo into Cells and Induce its Effective Leakage from the Vesicles to the Cytosol
Helin Räägel, Estonian Biocentre, Estonia |
16:45-17:10 |
Title: How arginine as an excipient affects the stability of concentrated protein formulations?
Dr. Dhawal Shah, National University of Singapore, Singapore |
17:10-17:30 |
Panel Discussion |
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Welcome Message
