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| Program |
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| BIT's 1 st Annual |
International Conference of Medichem-2010
Theme: Smart Chemistry in Drug Discovery
Time: May 18-20, 2010
Venue: Beijing International Convention Center, Beijing, China
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May 17, 2010 (Monday)
Registration
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Time |
08:00-18:00 |
Place |
3F, Beijing International Convention Center(BICC), China |
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May 18, 2010 (Tuesday)
Opening Ceremony and Keynote Forum |
Opening Ceremony
Time: 09:00-09:30, May 18, 2010 (Tuesday) Place: 305AB, 3F, BICC, China |
Keynote Forum
Time: 09:30-12:00, May 18, 2010 (Tuesday) Place: 305AB, 3F, BICC, China |
Moderator: |
Dr. Dingwei Yu, Associate Director, Cancer Innovation Medicine Center, AstraZeneca R&D, USA |
09:30-10:00 |
Title: Small Structural Units for Compound Property Modulation in Drug Discovery
Dr. Klaus Müller, Professor, Pharmaceutical Research, F. Hoffmann La- Roche AG, Switzerland |
10:00-10:30 |
Title: Mechanisms of Action and Transport of Platinum-Based Drugs: An Update
Dr. Giovanni Natile, Professor, Dipartimento Farmaco-Chimico, University of Bari, Italy |
10:30-11:00 |
Title: Chemical Biology Challenges for 21st Century Medicinal Chemistry
Dr. Tony Wood, Vice President, Head of Worldwide Medicinal Chemistry, Pfizer Global Research & Development, UK |
11:00-11:30 |
Title: Lead Optimization and Candidate Selection of Novel Allosteric MEK Inhibitors as Potential Anticancer Agents
Dr. Andreas Goutopoulos, Director, Medicinal Xhemistry, EMD Serono, Inc, USA |
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| Track 1: Target Structure and Fragment Based Drug Design and Synthesis |
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Track 1-1: Latest Breakthrough Topics
Time: 13:30-17:35, May 18, 2010 (Tuesday) Place: 310, 3F, BICC, China |
Session Chair: |
Dr. Benoît Déprez, Professor, Institut Pasteur De Lille, France |
Co-Chair: |
Dr. Srinivas Odde, Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, USA |
13:30-13:35 |
Welcome: Session Introduction |
13:35-14:00 |
Title: Moving Beyond Rules: The Development of a Central Nervous System Multi-Parameter Optimization (CNS MPO) Tool to Enable Alignment of Drug-like Properties
Dr. Xinjun Hou, Associate Research Fellow, Head of Neuroscience Computational Chemistry, Pfizer Pharma Therapeutics R＆D, USA |
14:00-14:25 |
Title: Unprecedented Natural Product-like Scaffolds for Fragment Based Drug Design and Synthesis
Dr. Dmitry Genis, CEO, ASINEX, Ltd. Russia |
14:25-14:50 |
Title: Adding a Dimension: Incorporating Predicted ADME Properties as a Diversity Dimension in Lead Follow-up
Dr. Robert D. Clark , Director, Life Sciences, Simulations Plus, Inc., USA |
14:50-15:15 |
Title: Discovery of Orally Active EP3 Receptor Antagonists
Dr. Jian Jin, Associate Professor and Director, Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina, USA |
15:15-15:30 |
Coffee Break |
15:30-15:55 |
Title: Structure-based Design of Receptor and Enzyme Modulators. Two Case Studies in Drug Discovery and Chemical Biology
Dr. Benoît Déprez, Professor, Institut Pasteur De Lille, France |
15:55-16:20 |
Title:Computational Discovery of Novel Low Micromolar LEDGF/p75-HIV-1 Integrase Disrupting Compounds
Dr. Srinivas Odde, Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, USA |
16:20-16:45 |
Title: Production of Human Drug Metabolites via Regioselective Monooxygenation Catalyzed by Secreted Peroxygenases from Fungi
Dr. Matthias Kinne, Research Associate, Junior Research Group Leader, International Graduate School of Zittau, Germany |
16:45-17:10 |
Title: Molecular Pharmacological Investigation Promotes the Develop of Calcium Blockades and the Elevation of Hypertension Therapeutic Effect
Dr. Wang zhengang, Professor, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, China |
17:10-17:35 |
Title: Control of Cell Surface Ion-channel Density as a Strategy for Regulation of the Cardiac Rhythm
Dr. Shetuan Zhang, Assistant Professor, Department of Physiology, Queen's University, Canada |
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Track 1-2: Receptors and Ion Channel Based Drug Design and Development
Time: 08:30-12:20, May 19, 2010 (Wednesday) Place: 310, 3F, BICC, China |
Chair |
Dr. Thomas Ryckmans, Senior Principle, Pfizer Discovery Chemistry, Global Research and Development, UK |
Co-Chair: |
Dr. Zhi-Qiang Yang, Research Fellow, Merck Research Laboratories, USA |
08:30-08:35 |
Welcome: Session Introduction |
08:35-09:00 |
Title: A Journey in Physico-chemical Property Space, From Lead to Drug Candidates: Metrics, Challenges and Progress in Peptidergic GPCRs Antagonists
Dr. Thomas Ryckmans, Senior Principle, Pfizer Discovery Chemistry, Global Research and Development, UK |
09:00-09:25 |
Title: Selective and Potent T-type Calcium Channel Antagonists Significantly Improve Sleep Architecture in Rodents and Non-human Primates
Dr. Zhi-Qiang Yang, Research Fellow, Merck Research Laboratories, USA |
09:25-09:50 |
Title: Recent Developments on Positive Allosteric Modulators of the AMPA Receptors and Their Therapeutic Promises
Dr. Bernard Pirotte,Professor, Department of Medicinal Chemistry, Drug Research Center, University of Liege, Belgium |
09:50-10:15 |
Title: Development of a New Strategy for Cancer Therapy: Targeting Ion Channels
Dr. Annarosa Arcangeli, Professor, Department of Experimental Pathology and Oncology, the University of Florence, Italy |
10:15-10:30 |
Coffee Break |
10:30-10:55 |
Title: Interaction between Membrane Proteins and Ions Studiedby ATR-FTIR Spectroscopy: A Potential Tool for Drug Screening
Dr. Yuji Furutani, Associate Professor, Division of Biomolecular Sensing, Department of Life and Coordination-Complex Molecular Science, Institute for Molecular Science, Japan |
10:55-11:20 |
Title: Extracellular Hsp70 as EGF Receptor Transactivator
Dr. Anton L. Evdonin, Senior Principle, Institute of Cytology RAS, Russia |
11:20-11:45 |
Title: Multi-parameter Analysis of EGF Receptor Pathway Activation
Dr. Matthew Hsu, R&D Director, Millipore Corporation, USA |
11:45-12:10 |
Title: Calcium Release-activated Calcium Channels as New Drug Targets for Proliferative Vascular Diseases
Dr. Xiang D. (Sean) Tang, Distinguished Professor and Chair, Department of Pharmacology, Nankai University School of Medicine, China |
12:10-12:20 |
Conclusion and Discussion |
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Track 1-3: Enzymes/Protein Target Based Drug Design and Development
Time: 13:30-17:30, May 19, 2010 (Wednesday) Place: 302, 3F, BICC, China |
Session Chair: |
Dr. Craig Tuerk, Professor, Biology and Chemistry, Morehead State University, USA |
Co-Chair: |
Dr. Tim Corson, CIHR Jean-François St-Denis Fellowship in Cancer Research, Department of Molecular, Cellular & Developmental Biology, Yale University, USA |
13:30-13:35 |
Welcome: Session Introduction |
13:35-14:00 |
Title: PI3Kg and PI3KdPartners in Crime in Inflammation First Comes First Serves?
Dr. Thomas Ruckle, Director of Discovery Project Management at Merck Serono, Switerland |
14:00-14:25 |
Title: Natural Product Mechanism of Action: Lessons from Triptolide
Dr. Tim Corson, CIHR Jean-François St-Denis Fellowship in Cancer Research, Department of Molecular, Cellular & Developmental Biology, Yale University, USA |
14:25-14: 50 |
Title: RNA Linking Library Presentation of Chemical Candidates for Binding to Target Proteins
Dr. Craig Tuerk, Professor, Biology and Chemistry, Morehead State University, USA |
14:50-15:15 |
Title: Potent and Selective Inhibitors of Phospholipase A2 as Novel Agents for the Treatment of Inflammatory Diseases and Neurological Disorders
Dr. George Kokotos, Director of Laboratory of Organic Chemistry, University of Athens, Greece |
15:15-15:30 |
Coffee Break |
15:30-15:55 |
Title: Therapeutic Drug Discovery Targeting Hypoxic Cancers with Carbohydrate-based Carbonic Anhydrase Inhibitors
Dr. Sally-Ann Poulsen, Chief Investigator & Associate Professor, Chemical Biology Group Eskitis Institute for Cell and Molecular Therapies, Griffith University, Australia |
15:55-16:20 |
Title: SAR Studies on Salacinol, A Potent a-glucosidase Inhibitor Isolated from Ayurvedic Traditional Medicine Salacia Reticulata
Dr. Osamu Muraoka, Professor, School of Pharmaceutical Sciences, Kinki University, Japan |
16:20-16:45 |
Title: Paclitaxel Conjugated to Nanoparticles for Selectively Targeting Cancer Cells
Dr. Reuben Jih-Ru Hwu, Prosessor, Department of Chemistry, National Tsing Hua University, Taiwan |
16:45-17:10 |
Title: Targeting Bcl-2 Proteins for Anti-cancer Treatment
Dr. Guillaume Lessene, Laboratory Head, The Walter and Eliza Hall Institute of Medical Research, Australia |
17:10-17:30 |
Conclusion and Discussion |
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Track 1-4: DNA/RNA Targeted Molecule Designs and Chemistry
Time: 08:30-10:15, May 20, 2010 (Thursday) Place: 310, 3F, BICC, China |
Session Chair: |
Dr. Peter E. Nielsen, Professor, Department of Cellular and Molecular Medicine, University of Copenhagen, Faculty Of Health Sciences, Denmark |
08:30-08:35 |
Welcome: Session Introduction |
08:35-08:55 |
Title: Aptamers as Regulators of Gene Expression and Tas Probes for Imaging Tumors
Dr. Jean-Jacques Toulmé, Director, European Institute of Chemistry and Biology, University of Bordeaux, France |
08:55-09：15 |
Title: Towards Novel Gene Targeted Drugs - Progress in Delivery of Peptide Nucleic Acid (PNA)
Dr. Peter E. Nielsen, Professor, Department of Cellular and Molecular Medicine, University of Copenhagen, Faculty Of Health Sciences, Denmark |
09:15-09:35 |
Title: Targeting DNA/RNA Unusual Structures
Dr. Jean-Louis Mergny, Laboratory Head , European Institute of Chemistry and Biology, INSERM U869, France |
09:35-09:55 |
Title: Pyrrole-imidazole Polyamide Conjugate as an Artificial Genetic Switch
Dr. Hiroshi Sugiyama, Professor, Department of Chemistry, Graduate School of Science, Kyoto University, Japan |
09:55-10:15 |
Title: DNA Photocleavage by DNA/LNA and PNA Conjugates
Dr. Eylon Yavin, Assistant Professor, The Institute for Drug Research, The School of Pharmacy, Hebrew University of Jerusalem, Israel |
10:15-10:30 |
Coffee Break |
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Track 1-5: Fragment-based Approaches in Drug Discovery
Time: 13:30-15:15, May 18, 2010 (Tuesday) Place: 311A, 3F, BICC, China |
Session Chair: |
Dr. MeihuaTu, Senior Principal Scientist, CVMED Chemistry, Pfizer Global Research & Development in Groton, USA |
13:30-13:35 |
Welcome: Session Introduction |
13:35-14:00 |
Title: A Yoctoliter-scale DNA Reactor for Small-molecule Evolution
Dr. Nils Jakob Vest Hansen, CEO, Vipergen Inc., Denmark |
14:00-14:25 |
Title: Fragments of Life™, A Metabolome-Inspired Fragment Library for FBDD Targeting Infectious Disease
Dr. Lance Stewart, CEO, Emerald BioStructures, Inc.,USA |
14:25-14:50 |
Title: Fragment-based Dynamic Combinatorial Library for Rapid Hit Generation
Dr. Beining Chen, Department of Chemistry, University of Sheffield, UK |
14:50-15:15 |
Title: Fragment-based Design at the Fragment Level
Dr. Paul C. D. Hawkins, Senior Applications Scientist, OpenEye Scientific Software, USA |
15:15-15:30 |
Coffee Break |
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| Track 2: Application of New Technologies and Tools for Medichem Studies |
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Track 2-1: Virtual Screening to Combinatorial Chemistry for Hit Findings （Part l）
Time: 13:30-17:10, May 18, 2010 (Tuesday) Place: 311B, 3F, BICC, China |
Track 2-1: Virtual Screening to Combinatorial Chemistry for Hit Findings （Part l）
Time: 13:30-17:10, May 18, 2010 (Tuesday) Place: 311B, 3F, BICC, China |
Session Chair: |
Dr. Bertho Gildas, Research Team Manager & Service Director, Laboratory of Pharmacological and Toxicological Chemistry and Biochemistry, Paris Descartes University, France |
Co-Chair: |
Dr. Shuxing Zhang, Assistant Professor, Department of Experimental Therapeutics, UT MD Anderson Cancer Center, USA |
13:30-13:35 |
Welcome: Session Introduction |
13:35-13:55 |
Title: Project Support by Automated Medicinal Chemistry
Dr. Christoph Huwe, Bayer Schering Pharma AG, Global Drug Discovery, Medicinal Chemistry, Germany |
13:55-14:15 |
Title: Advanced Methods in Fragment-based Drug Design and Virtual Screening Applications
Dr. Herbert Treutlein, Co-Founder and CEO, Qubist Molecular Design Pty. Ltd., Australia |
14:15-14:35 |
Title: Virtual Screening Analyses Using AuPosSOM
Dr. Bertho Gildas, Research Team Manager & Service Director, Laboratory of Pharmacological and Toxicological Chemistry and Biochemistry, Paris Descartes University, France |
14:35-14:55 |
Title: Design of CETP Inhibitors: A Comparison of Structure-based and Hand-picked Library Design Methods
Dr. MeihuaTu, Senior Principal Scientist, CVMED Chemistry, Pfizer Global Research & Development in Groton, USA |
14:55-15:15 |
Title: Industrial Dynamics and the Evolution of Combinatorial Chemistry
Dr. Stéphane Malo, Professor, Grenoble Ecole de Management, France |
15:15-15:30 |
Coffee Break |
15:30-15:50 |
Title: A Virtual Screening Led Journey from Endogenous Messengers to Drug-like Chemical Probes
Dr. Sridhar Vasudevan, BBSRC RSE Research Fellow, Department of Pharmacology, University of Oxford, UK |
15:50-16:10 |
Title: Target Centric Library Design
Dr. V N Balaji, Director and Chief Scientific Mentor, Jubilant Biosys Limited, India |
16:10-16:30 |
Title: High Throughput Screening and the Expensive Problem of Assay Interference Compounds
Dr. Jonathan Baell, Special Fellow and Laboratory Head , The Walter and Eliza Hall Institute of Medical Research Biotechnology Centre, Australia |
16:30-16:50 |
Title: Physics-based Scoring Method in Early Stages of Drug Discovery
Dr. Niu Huang, Assistant Investigator, National Institute of Biological Sciences, China |
16:50-17:10 |
Conclusion and Discussion |
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Track 2-2: Virtual Screening to Combinatorial Chemistry for Hit Findings （Part װ ）
Time: 08:30-12:20, May 19, 2010 (Wednesday) Place: 311A, 3F, BICC, China |
Session Chair: |
Dr. Xiang-Qun (Sean) Xie, Professor, University of Pittsburgh, , USA |
Co-Chair: |
Dr. Renxiao Wang, Professor, State Key Laboratory of Bioorganic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China |
08:30-08:35 |
Welcome: Session Introduction |
08:35-09:00 |
Title: 3D Pharmacophore Database Searches for Novel CB2 Ligands with Therapeutic Potential
Dr. Xiang-Qun (Sean) Xie, Professor, University of Pittsburgh, , USA |
09:00-09:25 |
Title: Virtual High Throughput Screening in Anticancer Drug Discovery
Dr. Jóhannes Reynisson, Lecturer in Computational Chemistry and Molecular Modelling, Department of Chemistry & Auckland Bioengineering Institute, The University of Auckland, The New Zealand |
09:25- 09:50 |
Title: A Novel Drug for Uncomplicated Malaria: Chemoinformatics Methods for Compound Selection in a High Throughput Screening Program
Dr. Neil G. Berry, Department of Chemistry, University of Liverpool, UK |
09:50-10:15 |
Title: Automatic Tailoring and Transplanting: A Novel Strategy for Lead Optimization in Structure-based Drug Design
Dr. Renxiao Wang, Professor, State Key Laboratory of Bioorganic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China |
10:15-10:30 |
Coffee Break |
10:30-10:55 |
Title: How Flow Chemistry Accelerates Lead Generation/Optimization
Dr. Laszlo Urge, CEO, ThalesNano Inc., Hungary |
10:55-11:20 |
Title: Exploiting Enzyme Plasticity and Reactivity in Virtual Screening: the Discovery of Glutamate Racemase Inhibitors with High Ligand Efficiency Values
Dr. M. Ashley Spies, Research Assistant Professor, Department of Biochemistry and The Institute for Genomic Biology, University of Illinois, USA |
11:20-11:45 |
Title: FORMA Therapeutics: Diversity Oriented Synthesis and other relevant technologies for Drug Discovery
Dr. Charles Johannes, Adjunct Professor & Director of Chemisty, FORMA Therapeutics, Nanyang Tecnological University, Singapore |
11:45-12:10 |
Title: Microwave Assisted Synthesis of Biologically Active Heterocycles
Dr. Santsoh Gaonkar, JSPS Postdoctoral Fellow, National Institute of Advanced Industrial Science and Technology (AIST), Japan |
12:10-12:20 |
Conclusion and Discussion |
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Track 2-3: Practical Organometallic Reactions for Chiral Drug Molecules
Time: 13:30-16:10, May 19, 2010 (Wednesday) Place: 303, 3F, BICC, China |
Session Chair: |
Dr. Maria Helena Garcia, Professor, Chemistry and Biochemistry Department, Faculty of Sciences of University of Lisbon, Portugal |
13:30-13:35 |
Welcome: Session Introduction |
13:35-14:00 |
Title: Can Organometallic Reactions Conducted In Situ Produce Species with Unique Bioactivities? Towards a Novel Discovery Tool for Chemical Biology
Dr. Filip Teplý, Laboratory of Organic Synthesis Head , Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Czech Republic |
14:00-14:25 |
Title: Bioorganometallic Chemistry: an Attractive Field for the Search of Anticancer Drugs
Dr. Maria Helena Garcia, Professor, Chemistry and Biochemistry Department, Faculty of Sciences of University of Lisbon, Portugal |
14:25-14:50 |
Title: Highly Efficient Transition Metal Catalyzed Asymmetric Synthesis of Drug Candidates
Dr. Lushi Tan, Distinguished Senior Investigator, Process Research, Merck & Co., Inc, USA |
14:50-15:15 |
Title: A New General Sulfinylating Process for Asymmetric Synthesis of Enantiopure Sulfinates and Sulfoxides
Dr. Bruce Lu, Senior Research Fellow, Boehringer-Ingelheim Pharmaceuticals, Inc, USA |
15:15-15:30 |
Coffee Break |
15:30-15:55 |
Title: Partially Hydrolysed Titanium Alkoxides as Remarkable Pre-catalysts in the Enantioselective Synthesis of Chiral Intermediates
Dr. Christina Chai, Program Manager, Institute of Chemical and Engineering Sciences, Singapore |
15:55-16:10 |
Conclusion and Discussion |
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Track 2-4: Bioprocess or Green Chemistry in Preclinical Compounds
Time: 10:30-12:15, May 20, 2010 (Thursday) Place: 310, 3F, BICC, China |
Session Chair: |
Dr. Yueju Wang, Assistant Professor of Biology, Macon State College, USA |
10:30-10:35 |
Welcome: Session Introduction |
10:35-11:00 |
Title: Production of Pharmaceutical Protein in Plants Via Site-specific Recombination Systems
Dr. Yueju Wang, Assistant Professor of Biology, Macon State College, USA |
11:00-11:25 |
Title: Synthesis of Highly Potent Peptide API under Lonza HAPI (Highly Potent Active Pharmaceutical Ingredients) Guideline
Dr. Yi Yang, Lonza Chemical R&D Tides, Lonza Ltd. Valais Works, Switzerland |
11:25-11: 50 |
Title: Non-Invasive Cancer Eradication (NICE) by Targeting Proliferative Protein Cdc6: Generating Cytonacx: a Novel Nanoparticle Carrying DNA or RNA Producing CDC6 shRNA
Dr. Luo Feng, Director of RNTein Biotech Lab., Inc., USA |
11:50-12:15 |
Title: An Effective Purification Method for Basic Compounds from Amine and Acid Condensation Reaction using SPE Technology
Dr. Lankun Song, Marketing Manager, Waters Technology (shanghai)Co. Ltd, China |
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Track 2-5: Bioinformatics and Computer Aided Drug Design and SAR Studies
Time: 13:30-17:30, May 20, 2010 (Thursday) Place: 302, 3F, BICC, China |
Session Chair: |
Dr. Jörg Grunenberg, Head of Scientific Computing, Institute of Organic Chemistry, TU Braunschweig, Germany |
Co-Chair: |
Dr. Umesh R. Desai, Professor of Medicinal Chemistry and Interim Director of Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, USA |
13:30-13:35 |
Welcome: Session Introduction |
13:35-13:55 |
Title: How Selective are Synthetic Lectins the Role of Anomeric Stabilization
Dr. Jörg Grunenberg, Head of Scientific Computing, Institute of Organic Chemistry, Germany |
13:55-14:15 |
Title: A Novel Approach in Probe Binding Site for Drug Discovery with Effective Screen Protein Database
Dr. Jiaan Yang, Vice President of Drug Discovery Technology, Sundia MediTech Company, Ltd., China |
14:15-14:35 |
Title: Combinatorial Virtual Library Screening to Design Heparin – Protein Interactions Modulators
Dr. Umesh R. Desai, Professor of Medicinal Chemistry and Interim Director of Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, USA |
14:35-14:55 |
Title: Conformer Sampling and Shape-based Virtual Screening
Dr. Paul C. D. Hawkins, Senior Applications Scientist, OpenEye Scientific Software, USA |
14:55-15:15 |
Title: Say No to Kinase: Targeting Akt Pleckstrin Homology Domain for Cancer Treatment
Dr. Shuxing Zhang, Assistant Professor, Department of Experimental Therapeutics, UT MD Anderson Cancer Center, USA |
15:15-15:30 |
Coffee Break |
15:30-15:50 |
Title: PubChem: The NIH BioActivity Database for Medicinal Chemistry Research
Dr. Yanli Wang, Associate Investigator, National Center for Biotechnology Information (NCBI), the National Institutes of Health (NIH), USA |
15:50-16:10 |
Title: Fragment Molecular Orbital Method: Application to Influenza Viral HA-sialoside Interaction
Dr. Toshihiko Sawada, National Institute of Advanced Industrial Science and Technology (AIST), Japan |
16:10-16:30 |
Title: QSAR Analysis of Calcium Channel Blockers in Concomitant Administration with Grapefruit Juice
Dr. Yoshihiro Uesawa, Associate Professor/Lecturer, Clinical Pharmaceutics Laboratory, Meiji Pharmaceutical University, Japan |
16:30-16:50 |
Title: Relative Binding Free Energy Estimation Between a Protein and a Ligand Based on the Free Energy Binding Principle
Dr. Takeshi Kikuchi, Professor, Department of Bioinformatics, College of Life Science, Ritsumeikan University, Japan |
16:50-17:10 |
Title: Drug Design by Modeling Chemical Reactions
Dr. Jun Xu, Professor of Medicinal Chemistry & CADD, Sun Yat-Sen University; Chairman, KMS Meditech, Inc., China |
17:10-17:30 |
Title: A Core Science in 21st Centry: Insilico Life Science
Dr. Huisheng Fang, Professor, Department of Bioinformatics, China Pharmaceutical University, China |
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| Track 3: Case Studies of Medichem on Drug Candidates on Major Diseases |
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Track 3-1: Medicinal Chemistry toward Anti-Cancer IND (Part I)
Time: 13:30-17:10, May 18, 2010 (Tuesday) Place: 311C, 3F, BICC, China |
Session Chair: |
Dr. Chuangxing Guo, Senior Principal Scientist, Cancer Chemistry, Pfizer Global Research and Development, USA |
Co-Chair: |
Dr. Dingwei Yu, Associate Director, Cancer Innovation Medicine Center, AstraZeneca R&D, USA |
13:30-13:35 |
Welcome: Session Introduction |
13:35-14:00 |
Title: Discovery of bRAF Preclinical Candidate
Dr. Chuangxing Guo, Senior Principal Scientist, Cancer Chemistry, Pfizer Global Research and Development, USA |
14:00-14:25 |
Title: Development of a Water-soluble Prodrug of Novel Topoisomerase I Inhibitor, TP300, that Overcame Drawbacks of Irinitecan
Dr. Nobuo Shimma, Associate Vice President, Research Division Fellow, Chugai Pharmaceutical Co. Ltd., Japan |
14:25-14:50 |
Title: Activation of Antisense Transcription by Camptothecin as a Basis to Develop Novel Therapeutics
Dr. Giovanni Capranico, Professor of Molecular biology, Department of Biochemistry, Bologna University, Italy |
14:50-15:15 |
Title: Discovery and Early Development of Novel Chk1 Kinase Inhibitor, AZD7762
Dr. Dingwei Yu, Associate Director, Cancer Innovation Medicine Center, AstraZeneca R&D, USA |
15:15-15:30 |
Coffee Break |
15:30-15:55 |
Title: Platinum Coordination Complexes. From DNA Interactions to New Anti-tumor Drug Design
Dr. Viktor Brabec, Professor, Institute of Biophysics, Academy of Sciences of the Czech Republic, Czech Republic |
15:55-16:20 |
Title: Synthesis of Potent Anticancer Naphthoquinone Esters with Structure-activity Relationship (SAR)
Dr. Ngampong Kongkathip, Head, Department of Chemistry, Faculty of Science, Kasetsart University, Thailand |
16:20-16:45 |
Title: An NHC Route to Novel Histone Deacetylase Inhibitors based upon the Natural Product Largazole
Dr. Bo Wang, Senior Research Associate, Department of Chemistry, The Ohio State University, USA |
16:45-17:10 |
Title: Honokiol Inhibits Tumor Growth and Metastasis via Suppressing PKC/MEK/ERK-dependent Matrix Metalloproteinase-9 Activation in HepG2 xenograft Model
Dr. Lijuan Chen, Professor, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, China |
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Track 3-1: Medicinal Chemistry toward Anti-Cancer IND (Part II)
Time: 08:30-12:20, May 19, 2010 (Wednesday) Place: 311B, 3F, BICC, China |
Session Chair: |
Dr. Giovanni Natile, Professor, Dipartimento Farmaco-Chimico, University of Bari, Italy |
Co-Chair: |
Dr. Giovanni Capranico, Professor of Molecular biology, Department of Biochemistry, Bologna University, Italy |
08:30-08:35 |
Welcome: Session Introduction |
08:35-09:00 |
Title:Synthesis and Biological Evaluation of Novel Antimitotic and Antivascular Combretastatin A-4 Analogues
Dr. Olivier Provot, Professor, University Paris XI, France |
09:00-09:25 |
Title: Inhibition of Matrix Metalloproteinases by Platinum Substrates
Dr. Giovanni Natile, Professor, Dipartimento Farmaco-Chimico, University of Bari, Italy |
09:25-09:50 |
Title:Design and Synthesis of Potential Non-peptidic Inhibitors of Grb2-SH2 Domain
Dr. Emmanuel Bertounesque, Senior Group Leader ,Institut Curie, Department of Medicinal Chemistry, France |
09:50-10:15 |
Title: Laminin-332-integrin Linteraction: a Target for Cancer Therapy
Dr. Daisuke Tsuruta, Department of Dermatology, Osaka City University, Graduate School of Medicine, Japan |
10:15-10:30 |
Coffee Break |
10:30-10:55 |
Title: The Effect of Sulfur-donor on the DNA Binding by Non-classical Platinum Anti-tumor Drugs
Dr. Yangzhong Liu, Professor, Department of Chemistry, University of Science and Technology of China, China |
10:55-11:20 |
Title: Small Molecular Peptidomimetics as Anticancer Agents
Dr. Wenfang Xu, Distinguished Professor, School of Pharmaceutical Sciences, Shandong University, China |
11:20-11:45 |
Title: Retro-MedChem: From Natural Products to Drugs and Back Again
Dr. Martin J. Lear, Assistant Professor, National University of Singapore (NUS), Singapore |
11:45-12:10 |
Title: Anti-tumor Compounds Derived from Natural Products
Dr. Qingshan Li, Professor, School of Pharmaceutical Sciences, Shanxi Medical University, China |
12:10-12:20 |
Conclusion and Discussion |
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Track 3-2: Medicinal Chemistry toward Anti-Infectious Diseases (Part I)
Time: 13:30-17:00, May 19, 2010 (Wednesday) Place: 305A, 3F, BICC, China |
Session Chair: |
Dr. Mark E. Flanagan, Senior Principal Scientist, Pfizer World Wide Medicinal Chemistry, USA |
Co-Chair: |
Dr. Kun Liu, Senior Research Fellow , External Discovery and Preclinical Sciences, Merck Research Laboratories, USA |
13:30-13:35 |
Welcome: Session Introduction |
13:35-14:00 |
Title: Discovery of Azetidinyl Ketolides for the Treatment of Susceptible and Multidrug Resistant Community-acquired Respiratory Tract Infections
Dr. Mark E. Flanagan, Senior Principal Scientist, Pfizer World Wide Medicinal Chemistry, USA |
14:00-14:25 |
Title: Discovery of Novel P4 Modified Macrocyclic Hepatitis C Virus NS 3 Protease Inhibitors with Improved Mutant-resistance Profile and Pharmacokinetic Property
Dr. Maosheng Duan, Chief Scientist, GlaxoSmithKine, USA |
14:25-14:50 |
Title: Chemical Approaches for Antimicrobial Agents
Dr. Frederic Guittard, Professor, Université de Nice-Siophia Antipolis, France |
14:50-15:15 |
Title: Spirotetrahydro β-carbolines (spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria
Dr. Bin Zou, Research Investigator, Novartis Institute for Tropical Diseases, Singapore |
15:15-15:30 |
Coffee Break |
15:30-15:55 |
Title: Iinhibition of Influenza Virus Infection by Novel Tea Catechin Derivatives
Dr. Kunihiro Kaihatsu, Assistant Professor, Osaka University, Japan |
15:55-16:20 |
Title: Nitroimidazo-oxazines : Structure Activity Relationships in Replicating and Nonreplicating Mycobacterium Tuberculosis (Mtb)
Dr. Jan Jiricek, Research Investigator II Chemistry, Novartis Institute for Tropical Diseases, Singapore |
16:20-16:45 |
Title：Synthesis and Antibacterial Activity of Thiazomycin Analogs
Dr. Kun Liu, Senior Research Fellow , External Discovery and Preclinical Sciences, Merck Research Laboratories, USA |
16:45-17:00 |
Conclusion and Discussion |
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Track 3-2: Medicinal Chemistry toward Anti-Infectious Diseases (Part II)
Time: 13:30-16:20, May 20, 2010 (Thursday) Place: 303, 3F, BICC, China |
Session Chair: |
Dr. Zhiwen Jonathan Zhang, Assistant Professor, College of Pharmacy, Division of Medicinal Chemistry, The University of Texas at Austin, USA |
Co-chair |
Dr. Y. Whitney Yin, Assistant Professor, Institute of Cellular and Molecular Biology, Department of Chemistry and Biochemistry, University of Texas at Austin, USA |
13:30-13:35 |
Welcome: Session Introduction |
13:35-14:00 |
Title: Identification of Novel Drug Target for Development of Anti‐infective Agents
Dr. Zhiwen Jonathan Zhang, Assistant Professor, Division of Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, USA |
14:00-14:25 |
Title: Discovery of Novel Inhibitors of Bacterial MurD and MurE Ligases by Structure-based Virtual Screening Approach
Dr. Tom Solmajer, Professor of Medicinal Chemistry, National Institute of Chemistry, Slovenia |
14:25-14:50 |
Title：Structural Insight on Anti-HIV Drug Toxicity
Dr. Y. Whitney Yin, Assistant Professor, Institute of Cellular and Molecular Biology, Department of Chemistry and Biochemistry, University of Texas at Austin, USA |
14:50-15:15 |
Title: Development and Optimization of Novel Anti-Flaviviral Compounds
Dr. Susan M. Keenan, Assistant Professor, School of Biological Sciences, University of Northern Colorado, USA |
15:15-15:30 |
Coffee Break |
15:30-15:55 |
Title: Targeting Exoerythrocytic, Erythrocytic and Sexual Stages of Malaria Parasites: a Challenging Task
Dr. Rui Moreira, Institute for Research in Medicines and Pharmaceutical Sciences, Faculty of Pharmacy, University of Lisbon, Portugal |
15:55-16:20 |
Title: Synthesis and Screening of Antibiotic Lead Drugs on Scaffold of Natural Macrocyclic Peptides
Dr. Chuanguang Qin, Professor, Faculty of Life Science, Northwestern Polytechnical University, China |
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Track 3-3: Medicinal Chemistry toward Anti-Neurodegenerative IND
Time: 08:30-12:35, May 20, 2010 (Thursday) Place: 311A, 3F, BICC, China |
Session Chair: |
Dr. Spiros Liras, Executive Director and Department Head, CVMED Medicinal Chemistry, Pfizer, USA |
Co-Chair: |
Dr. Yuegang Zuo, Professor, Department of Chemistry and Biochemistry, University of Massachusetts Dartmouth, USA |
08:30-08:35 |
Welcome: Session Introduction |
08:35-09:00 |
Title: Phosphodiesterase Inhibitors as treatments for Major Disorders of the Central Nervous System; The pursuit of a Research Platform
Dr. Spiros Liras, Executive Director CVMED Medicinal Chemistry, Pfizer Inc. , USA |
09:00-09:25 |
Title:Structure-based Design and Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors for the Treatment of Schizophrenia
Dr. Xinjun Hou, Associate Research Fellow, Head of Neurosciences Computational Chemistry, Pfizer Pharma Therapeutics R＆D, USA |
09:25-09:50 |
Title: A2A Antagonist for Parkinson’s Disease
Dr. Xiaohu Zhang, Senior Director of Medicinal Chemistry, BioDuro –PPD, USA |
09:50-10:15 |
Title: Novel α7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Alzheimer’s Disease and Schizophrenia
Dr. Bruce N Rogers, Senior Director, Neuroscience Medicinal Chemistry, Pfizer Inc, USA |
10:15-10:30 |
Coffee Break |
10:30-10:55 |
Title: Oxazole GSK-3beta Inhibitors for Alzheimer’s Disease - from HTS Hit to Efficacious Lead
Dr. Jinshan Michael Chen, Principal Scientist , Pfizer Global Research & Discovery, USA |
10:55-11:20 |
Title: Examination of Anthraquinones in a Traditional Chinese Herbal Medicine, Radix Polygoni Multiflori, and their Effects on a Parkinson's Disease Biomarker
Dr. Yuegang Zuo, Professor, Department of Chemistry and Biochemistry, University of Massachusetts Dartmouth, USA |
11:20-11:45 |
Title: Therapeutic And Preventive Measures for Mild Cognitive Impairment By Chinese Herbal Medicine Utilizing a Potential Blood Biomarker
Dr. Akira Matsumoto, Professor, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan |
11:45-12:10 |
Title: Metal Ions in Protein Oligomerization
Dr. Fabio Arnesano, Research Scientist, Dipartimento Farmaco-Chimico, University of Bari, Italy |
12:10-12:35 |
Title: NMDA Receptors Mediate Excitotoxicity in Amyloid Beta-induced Synaptic Pathology of Alzheimer’s Disease
Dr. Yan Wu, Associate Professor, Capital Medical University, China |
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Track 3-4: Medicinal Chemistry toward Anti- Diabetes & Obesity
Time: 13:30-16:40, May 20, 2010 (Thursday) Place: 310, 3F, BICC, China |
Chair |
Dr. Sharma S Prabhakar, Vice-President, American Federation for Medical Research; Professor and Chief, Division of Nephrology and Hypertension; Vice-Chairman, Department of Medicine; Professor, Department of Cell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, USA |
Co-Chair: |
Dr. Gui-Bai Liang, Senior Research Fellow, Merck External Basic Research, USA |
13:30-13:35 |
Welcome: Session Introduction |
13:35-14:00 |
Title: Discovery of GCC2680 as a Potent, Selective and Orally Efficacious Cannabinoid-1 Receptor Antagonist
Dr. Jinhwa Lee, Research Director, Green Cross Corp. , Korea |
14:00-14:25 |
Title: Novel Therapeutic Approaches to Diabetic Nephropathy
Dr. Sharma S Prabhakar, Professor and Chief, Division of Nephrology and Hypertension; Vice-Chairman, Department of Medicine, Texas Tech University Health Sciences Center, USA |
14:25-14:50 |
Title: Diabetes, Januvia, and Beyond - Medicinal Chemistry of DPP-4 Inhibitors
Dr. Gui-Bai Liang, Senior Research Fellow, External Discovery and Preclinical Sciences, Merck & Co., Inc., USA |
14:50-15:15 |
Title:Discovery of Carmegliptin: A Potent and Long-acting Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
Dr. Patrizio Mattei, Medicinal Chemist, Discovery Chemistry, F. Hoffmann-La Roche AG, Switzerland |
15:15-15:30 |
Coffee Break |
15:30-15:55 |
Title:Drug Discovery for Diabetic Neuropathy
Dr. Irina G.Obrosova, Professor of Biomedical Sciences; Director, Mechanisms of Diabetes Complications Laboratory, USA |
15:55-16:20 |
Title: 11β-hydroxysteroid DehydroGenase Type 1-targeted Drug Development for Diabetes: Status and Research in Our Group
Dr. Guang Liang, Associate Professor, Director of Bioorganic & Medicinal Chemistry Research Center, Wenzhou Medical College, China |
16:20-16:40 |
Conclusion and Discussion |
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About ICM
