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| Event Organizer: 2008 World Cancer Congress, Shanghai, China |
| Symposium Chair
Dr. Sohaib Khan, Professor of Cell & Cancer Biology, Director, NCI Training Program in Cancer
Program Director, Barrett Cancer Center, Vontz Center for Molecular Studies, UC College of Medicine, USA |
Distinguished Symposium Faculty Members Invited
Dr. Elwood V. Jensen, Distinguished Professor, University of Cincinnati, 2004 Albert Lasker Medical Award Winner, USA
Dr. Ron Evans, Professor, Gene Expression Laboratory, Salk Institute, USA
Dr. Bert O'Malley, Professor and Chairman, Department of Molecular & Cellular Biology, Baylor College of Medicine, USA
Dr. Craig Jordan, Professor, Vice President and Research Director for Medical Sciences, Alfred G. Knudson Chair of Cancer Research, Fox Chase Cancer Center, USA
Dr. Jan-Ake Gustafsson, Professor of Medical Nutrition and Chairman of the Dept of Biosciences and Nutrition, Karolinska Institutet, Sweden
Dr. Benita Katzenellenbogen, Professor, Molecular and Integrative Physiology, University of Illinois, USA
Dr. John Baxter, Professor, University of California, San Francisco, USA |
Speakers of Parallel Sessions are under Organization |
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A Great Scientist Devotes Life
to Cancer Research |
Keynote Speaker: Dr. Elwood V. Jensen
Distinguished Professor, University of Cincinnati, 2004 Albert Lasker Medical Award Winner, USA
Dr. Jensen, known for concluding his lectures in verse, neatly summed up what his extraordinary series of discoveries might mean to a woman who has been diagnosed with breast cancer:
A lady with growth neoplastic
Thought surgical ablation too drastic
She preferred that her ill
Could be cured with a pill
Which today is no longer fantastic
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Symposium Overview
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As every previous life spring forum initiated by BIT Life Sciences, the 5th Life Spring Forum will offer the Commemorate Symposium on Nuclear Receptor will be held in on June 13-14, 2008, Everbright Convention and Exhibition Center, Shanghai, China, to celebrate 50 years of Dr. Elwood Jensen's Glory in Discovering Estrogen Receptors. Besides, the symposium is aim to create an intensive and stimulating atmosphere where authorities from the world scientific community will present and discuss the frontier of researches in the field of Nuclear Receptor, through which the dynamic program will create more opportunities for exchange of ideas between scientists interested in this area and further collaboration in Asia. Also with this symposium, we hope to display Dr. Jensen's considerable influence in the fields of Nuclear Receptors which generate huge impact in understanding the essence of life and the mechanism of many diseases, also having paved a boulevard for therapeutic discovery and development to cure numerous life threatening severe diseases. |
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| Historical Review on the Development of Estrogen Receptors |
| The content could be provided by Dr. Jensen |
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| A Devoting Scientist's Unforgettable Moments |
-Historical Documents and Compilation
Need electronic copies of your reference, remembrance photos, assays, articles, first paper on Estrogen Receptor, family member description, important historical papers or even your poems and prose for the dedicated proceeding. |
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Age 38 |
Age 45 |
Age 58 |
Age 84 |
Age 88 |
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Introduction to Nuclear Receptors |
Nuclear receptors are a family of transcription factors the activity of which is modulated by binding to small signalling molecules. These compounds trigger changes in the conformational and dynamic behaviour of the receptors, which in turn regulate the recruitment of co-regulators and chromatin-modifying machineries. Nuclear receptors regulate growth, development and metabolic homeostasis in multicellular organisms in which hormones and non-hormonal substances, such as intracrine regulatory metabolites, signal the status of the organism as a whole. Several synthetic ligands can specifically modulate the communication of a nuclear receptor with its cellular environment. Lipid-soluble hormones and vitamins can pass easily through the lipid bilayer of cell membranes, triggering an intercellular communication network in which nuclear receptors exert genomic and non-genomic actions that are determined by the specific recognition of the ligand. Nuclear receptors are one of the main classes of transcriptional regulators in metazoans—there are 48 in humans—and they first appeared in the earliest stages of animal evolution, long before the divergence of vertebrates and invertebrates. Steroid receptors were first identified biochemically in the 1960s (Jensen, 2004), but nuclear receptors were only recognized as a superfamily of transcription factors 20 years ago (Green et al, 1986; Hollenberg et al, 1985; Miesfeld et al, 1986). The family includes disguised 'orphan receptors', which are awaiting ligand identification, and true orphans, which regulate transcription independently of ligand binding.
Today, the nuclear receptor field has broadened dramatically and covers areas ranging from structural and functional analyses of the molecular mechanisms of transcription regulation to nuclear-receptor-based drug design and (pre)clinical studies aimed at exploiting the potential of these master regulators for therapy, particularly of metabolic diseases and cancer (Chambon, 2004; Evans, 2004). This Symposium on Nuclear Receptors was special because 2008 marked the 50th anniversary of Estrogen Receptors discovery by Elwood Jensen. The organizers put together an exciting and dense program as below.
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Tentative Program
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Time: June 12-13, 2008, |
Venue: Everbright Convention and Exhibition Center, Shanghai, China |
Ceremony & Academic Symposium For One Great Scientist's Golden Life |
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Time: June 12, 2008
Place: Grand Ballroom, Everbright Convention and Exhibition Center, Shanghai |
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Celebration & Keynote Speech |
18:30-18:40 |
Chair's Opening Remark
Chair: Dr. Sohaib Khan, Professor of Cell & Cancer Biology, Director, NCI Training Program in Cancer
Program Director, Barrett Cancer Center, Vontz Center for Molecular Studies, UC College of Medicine, USA
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18:40-19:20 |
Keynote Speech
Title: The Discovery of Nuclear Receptors
Dr. Elwood Jensen, Distinguished Professor, University of Cincinnati, 2004 Albert Lasker Medical Award Winner, USA |
19:20-20:30 |
Banquet for Celebrating 50 Years of Professor Elwood Jensen’s Science |
Time: June 13, 2008
Place: No. 11 Room, 2F, Everbright Convention and Exhibition Center, Shanghai |
Time |
Plenary Presentations |
Chair: Dr. Sohaib Khan, Professor of Cell & Cancer Biology, Director, NCI Training Program in Cancer
Program Director, Barrett Cancer Center, Vontz Center for Molecular Studies, UC College of Medicine, USA |
Session 1: Molecular & Cell Biology in Oncology (Part 1) |
08:30-08:50 |
Title: Regulation of Estrogen Receptor Alpha Level and Hormone Binding Capacity in MCF-7 Breast Cancer Cells. Underlying Mechanism and Influence of Ligands
Dr. Guy Leclercq, Professor, Director of J.-C. Heuson Laboratory of Breast Cancerology, Bordet Institute, Belgium
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08:50-09:10 |
Title: Regulation of Progesterone Receptor Isoforms Expression in Human Astrocytomas
Dr. Ignacio Camacho-Arroyo, Department of Chemistry, National Autonomous University of Mexico, Mexico
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Session 2: New Signaling, Dynamics and Regulations of Steroid NRs |
09:10-09:30 |
Title: The Interaction Between Hepatitis B Virus X Protein and Nuclear Receptor-Related Proteins Triggers a Cascade of Signal Transduction Activations
Dr. Runtao He, Principal investigator, Department of Virology, National Microbiology Lab, Public Health Agency of Canada, Canada
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09:30-09:50 |
Title: Dissociation of BRCA1's DNA Repair and Checkpoint Functions from DNA Damage-Induced Cytotoxicity: A Dependence on BRCA1 Localization in Sporadic Breast Cancer
Dr. Fen Xia, Assistant Professor, Vanderbilt University Medical School, Ingram Cancer Center, USA
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09:50-10:10 |
Tea Break |
Session 3: Mechanisms of Actions by Diversified Orphan NRs |
10:10-10:30 |
Title: Extra-Nuclear vs Nuclear Estrogen Signaling: Who Has the Last Word in Estrogen Stimulated Mammary Tumorigenesis?
Dr. Zhao-Yi Wang, Prevedel Professor, Department of Surgery and Pathology, Creighton University Medical School, USA
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10:30-10:50 |
Title: PPAR α Function is Under the Control of the Circadian PARbZip Transcription Factors
Dr. Frédéric Gachon, Equip Avenir INSERM, Human Institute of Genetics, Montpellier, France
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Session 4: Developmental Characteristics of NRs |
10:50-11:10 |
Title: Nuclear Receptor Cofactors during Brain Development
Dr. Anastasia Galeeva, Department of Developmental Biology, Medical School of Tampere University, Finland
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Session 5: Defining and Redefining Coregulatory Factors of NRs |
11:10-11:30 |
Title: The Two-Faced Nature of Steroid Receptor RNA Activator: A Potential New Target to Fight Hormone Dependent Cancer?
Dr. Etienne Leygue, Associate Professor of Department of Biochemistry & Medical, Faculty of Medicine, University of Manitoba, Canada
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Session 6: NRs and Cancer |
13:30-13:50 |
Title: Oncogenic Conversion of the Thyroid Hormone Receptor
Dr. Lizabeth A. Allison, Professor, Department of Biology, College of William and Mary, Williamsburg, USA
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13:50-14:10 |
Title: Discovering Novel Compounds and Pathways that May Target the Intracellular Activity of Androgen Receptor in Prostate Cancer
Dr. Pei-Wen Hsiao, Assistant Research Fellow, Agricultural Biotechnology Research Center, Taiwan, China
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14:10-14:30 |
Title: Nuclear Receptors and Estrogen Homeostasis in Ovarian Cancer
Dr. Theresia Thalhammer, Associate Professor, Department of Pathophysiology, Medical University of Vienna, Vienna, Austria |
Session 7: NRs and CNS Disorders
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14:30-14:50 |
Title: Altered Levels and Activities of Nuclear Receptors Are Responsible for Impaired Cholesterol Homeostasis, High Levels of β-and γ-Secretase Activities and Aβ Production in Alzheimer’s Brain
Dr. Wandong Zhang, Senior Research Officer, Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada
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14:50-15:10 |
Title: Treatment Modalities for Glioblastoma Multiforme
Dr. Ramazan DURMAZ, Associated Professor, Department of Neurosurgery, Medical School, Eski?ehir Osmangazi University, Turkey |
15:10-15:30 |
Tea Break |
Session 8: NRs and Metabolic Disorders |
15:30-15:50 |
Title: FXR Agonists for the Treatment of Metabolic Syndrome and Medical Complications Thereof
Dr. Claus Kremoser, CEO, Phenex Pharmaceuticals AG, Werksgelaende BASF, Ludwigshafen, Germany
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15:50-16:10 |
Title: Hypercholesterolemia in Rats with Hepatomas: Increased Oxysterols Accelerate Efflux but does not Inhibit Biosynthesis of Cholesterol
Dr. Yasushi Matsuzaki, Department of Gastroenterology, Tokyo Medical University, Kasumigaura Hospital, Japan
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Session 9: NRs and Cardiovascular, Inflamation, Muscle Diseases and Other Disorders |
16:10-16:30 |
Title: Reduction of the Activity of Glucocorticoid Receptors in Hemorrhagiс and Traumatic Shock as a Possible Cause of the Disturbances in the Regulation of Vascular Tone by Vasoconstrictive Agonists
Dr. Pavel V. Avdonin, Professor, N.K.Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Russia
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Session 10: Medicinal Chemistry of NRs Modulators |
16:30-16:50 |
Title: Sulfotransferase Gene Regulation and Nuclear Receptors
Dr. Guangping Chen, Associate Professor, Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, USA |
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The Commemorate Symposium is part of the World Cancer Congress-2008, and therefore same registration condition will apply for all potential applicants. However, all registered participants or speakers at World Cancer Congress-2008 can free access to this symposium with name tag or free pass issued upon registration desk. Otherwise, you need to go to the registration page to process your attendance by click here. If you register at this symposium, you will also receive free package to all other scientific and social programs at the Summit as other session participants. |
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| Register |
The total number of participants is limited to 250 in order to preserve the ambience of the meeting. The meeting will be limited to 250 participants. Priority will be given to those presenting abstracts. There may be a limit on numbers of participants from the same laboratory. Click here to register. Please register by May 30th 2008.
This will create many opportunities for exchange of ideas between scientists interested in this area and further collaboration. Free communications will be presented in the form of posters. A limited number of free communications will be selected for oral presentations. For more information please see registration information. |
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Dr. Andrew V. Schally Professor, Veterans Affairs, The Nobel Prize in Physiology or Medicine 1977, USA |
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Dr. Elwood V. Jensen
Distinguished Professor, University of Cincinnati, 2004 Albert Lasker Medical Award Winner, USA |
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Dr. Alan Garen
Professor, Yale University, Member, National Academy of Sciences, USA
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Dr. Francis P. Crawley
Executive Director, Expert in Ethics of World Health Organization, Belgium |
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Dr. Iqbal S. Grewal,
Vice President, Preclinical Therapeutics, Seattle Genetics, Inc., USA |
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Dr. Samir N. Khleif,
Senior investigator and Chief of Cancer Vaccine Section at the NCI, USA |
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Dr.Stephen D. Barnhill, Chairman and Chief Executive Officer,
Health Discovery Corporation, USA |
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Dr. Samuel S. Epstein,
Chairman, Cancer Preven-tion Coalition, USA |
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BIT's World Cancer Congress 2008 looks for ward to welcoming you to Shanghai for a stimulating scientific program and memorable social events and looking for partners for the common wealth |
| of World Cancer Congress. Interested in to learn more or sponsor the congress? Join us Today! |
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WSA-2008
(July 20-26, 2008, Kunming, China) |
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CEMD-2008
(Oct.22-28, 2008, Beijing & Xi'an, China) |
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WCG 2008
(Dec. 5-7, 2008, Guangzhou, China) |
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